Can erythropoietin be used to prevent brain damage in cerebral malaria?

被引：35

作者：

Casals-Pascual, Climent ^{[1
]}

Idro, Richard ^{[2
,3
]}

Picot, Stephane ^{[4
]}

Roberts, David J. ^{[5
,6
]}

Newton, Charles R. J. C. ^{[2
,7
,8
]}

机构：

[1] MRC Labs, Fajara, Gambia

[2] Kenya Govt Med Res Ctr, Ctr Geog Med Coast, Kilifi, Kenya

[3] Makerere Univ, Mulago Hosp, Dept Paediat, Kampala, Uganda

[4] Univ Lyon 1, EA4170, Malaria Res Unit, F-69365 Lyon, France

[5] John Radcliffe Hosp, Nuffield Dept, Clin Sci Lab, Oxford OX3 9BQ, England

[6] John Radcliffe Hosp, Natl Blood Serv, Oxford Ctr, Oxford OX3 9BQ, England

[7] UCL, Inst Child Hlth, Neurosci Unit, London, England

[8] London Sch Hyg & Trop Med, Clin Res Unit, London WC1, England

来源：

TRENDS IN PARASITOLOGY | 2009年 / 25卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

PLASMODIUM-FALCIPARUM MALARIA; TRANSCRIPTIONAL REGULATORY ELEMENTS; TISSUE-PROTECTIVE CYTOKINE; HYPOXIA-INDUCIBLE FACTOR; ENCODING GENE CONTAINS; CARBAMYLATED ERYTHROPOIETIN; NEURONAL APOPTOSIS; FLANKING REGION; SEVERE ANEMIA; BONE-MARROW;

D O I：

10.1016/j.pt.2008.10.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Erythropoietin (Epo) modulates the survival of developing erythroid cells and the production of new erythrocytes in the bone marrow and is a key molecule in the adaptation to hypoxia and anaemia. Epo receptors have been found to be widely expressed on nonhaematopoietic cells, and Epo has been shown to have diverse actions (in particular, preventing ischaemic damage to tissues of the central nervous system). Recently, Epo has been shown to improve the outcome in a murine model of malaria, and high plasma levels of Epo in children with cerebral malaria were associated with a better outcome. Here, we review the biological importance of Epo, its mechanisms of action and the rationale for the proposed use of Epo as an adjunct treatment in cerebral malaria.

引用

页码：30 / 36

页数：7

共 62 条

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