Identification of Ten Long Noncoding RNAs as Biomarkers for Hepatocellular Carcinoma

被引：0

作者：

Lin, Chao ^{[1
,2
]}

Zhang, Dan ^{[2
]}

Yao, Xiaoxiao ^{[2
]}

Liu, Shui ^{[2
]}

Xiang, Yien ^{[2
]}

Zhang, Xuewen ^{[2
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Dept Hepatobiliary Pancreat Surg, Changchun, Jilin, Peoples R China

[2] Jilin Univ Second Hosp, Dept Hepatobiliary & Pancreat Surg, Changchun, Jilin, Peoples R China

来源：

BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY | 2020年 / 63卷

关键词：

long noncoding RNAs; hepatocellular carcinoma; biomarkers; LIVER-CANCER; NETWORK;

D O I：

10.1590/1678-4324-2020190511

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Long-chain non-encoded RNAs (lncRNAs) are important in many life activities and can participate in the occurrence of hepatocellular carcinoma (HCC). Moreover, IncRNAs can be used as basis for developing new strategies to hinder liver cancer. To investigate the utility of IncRNAs in HCC as potential biomarkers for early detection and diagnosis, we mined genomic data from the Cancer Genome Atlas (TCGA), and analyzed the gene expressions from 374 tumor patients and 50 normal patients. The abnormal expressions of 387 differentially expressed IncRNAs (DElncRNAs) were identified from a total of 3099 lncRNAs. Moreover, 18 modules were divided based on WGCNA, and 2 of the 18 modules were positively correlated with stage and grade, and negatively correlated with survival time. Finally, 10 lncRNAs were found and their main functions are the enhancement of cellular metabolic capacity and cell proliferation. These 10 lncRNAs may serve as novel prognostic markers and therapeutic targets, and may help guide subsequent studies on HCC.

引用

页数：8

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