Cyanidin inhibits EMT induced by oxaliplatin via targeting the PDK1-PI3K/Akt signaling pathway

被引：33

作者：

Li, Xiang ^{[1
,2
,3
]}

Zhang, Ze-sheng ^{[3
]}

Zhang, Xiao-han ^{[3
]}

Yang, Sheng-nan ^{[3
]}

Liu, Dong ^{[3
]}

Diao, Cui-ru ^{[3
]}

Wang, Hao ^{[2
]}

Zheng, Fu-ping ^{[2
]}

机构：

[1] Yancheng Teachers Univ, Sch Marine & Biol Engn, Yancheng 224051, Peoples R China

[2] Beijing Technol & Business Univ, Beijing Lab Food Qual & Safety, Beijing 100048, Peoples R China

[3] Tianjin Univ Sci & Technol, State Key Lab Food Nutr & Safety, Tianjin 300457, Peoples R China

来源：

FOOD & FUNCTION | 2019年 / 10卷 / 02期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; HEPATOCELLULAR-CARCINOMA; CANCER; INDUCTION; CELLS; ANTHOCYANINS; CHEMOTHERAPY; SUPPRESSION; METASTASIS; PROLIFERATION;

D O I：

10.1039/c8fo01611a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anthocyanins have been shown to exhibit antitumor activity in several cancers in vitro and in vivo. Oxaliplatin is widely used as an anti-cancer drug. However, a large proportion of patients receiving platinum-based anti-cancer drug treatments will relapse because of metastasis and drug resistance. The aim of this study is to discover an effective anthocyanin that possesses the combinational anti-metastatic effects of oxaliplatin. Our results showed that cyanidin, one of the main constituents of anthocyanins, widely found in black rice, black bean, Hawthorn and other foods, could reverse drug resistance and enhance the effects of oxaliplatin on hepatic cellular cancer (HCC). Cyanidin inhibited migration and reversed EMT biomarker changes induced by low dose OXA. Moreover, 3-phosphoinositide-dependent protein kinase 1 (PDK1) can be considered a potential target and cyanidin significantly increased OXA sensitivity and inhibited the EMT induced by OXA via PI3K/Akt signaling in HCC.

引用

页码：592 / 601

页数：10

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