Cyanidin inhibits EMT induced by oxaliplatin via targeting the PDK1-PI3K/Akt signaling pathway

被引：33

作者：

Li, Xiang ^{[1
,2
,3
]}

Zhang, Ze-sheng ^{[3
]}

Zhang, Xiao-han ^{[3
]}

Yang, Sheng-nan ^{[3
]}

Liu, Dong ^{[3
]}

Diao, Cui-ru ^{[3
]}

Wang, Hao ^{[2
]}

Zheng, Fu-ping ^{[2
]}

机构：

[1] Yancheng Teachers Univ, Sch Marine & Biol Engn, Yancheng 224051, Peoples R China

[2] Beijing Technol & Business Univ, Beijing Lab Food Qual & Safety, Beijing 100048, Peoples R China

[3] Tianjin Univ Sci & Technol, State Key Lab Food Nutr & Safety, Tianjin 300457, Peoples R China

来源：

FOOD & FUNCTION | 2019年 / 10卷 / 02期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; HEPATOCELLULAR-CARCINOMA; CANCER; INDUCTION; CELLS; ANTHOCYANINS; CHEMOTHERAPY; SUPPRESSION; METASTASIS; PROLIFERATION;

D O I：

10.1039/c8fo01611a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anthocyanins have been shown to exhibit antitumor activity in several cancers in vitro and in vivo. Oxaliplatin is widely used as an anti-cancer drug. However, a large proportion of patients receiving platinum-based anti-cancer drug treatments will relapse because of metastasis and drug resistance. The aim of this study is to discover an effective anthocyanin that possesses the combinational anti-metastatic effects of oxaliplatin. Our results showed that cyanidin, one of the main constituents of anthocyanins, widely found in black rice, black bean, Hawthorn and other foods, could reverse drug resistance and enhance the effects of oxaliplatin on hepatic cellular cancer (HCC). Cyanidin inhibited migration and reversed EMT biomarker changes induced by low dose OXA. Moreover, 3-phosphoinositide-dependent protein kinase 1 (PDK1) can be considered a potential target and cyanidin significantly increased OXA sensitivity and inhibited the EMT induced by OXA via PI3K/Akt signaling in HCC.

引用

页码：592 / 601

页数：10

共 36 条

[1] Discovery of PDK1 Kinase Inhibitors with a Novel Mechanism of Action by Ultrahigh Throughput Screening [J].

Bobkova, Ekaterina V. ;

Weber, Michael J. ;

Xu, Zangwei ;

Zhang, Yan-Ling ;

Jung, Joon ;

Blume-Jensen, Peter ;

Northrup, Alan ;

Kunapuli, Priya ;

Andersen, Jannik N. ;

Kariv, Ilona .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (24) :18838-18846

[2]

BOURHIS J, 1994, LARYNGOSCOPE, V104, P468

[3] Black Rice Anthocyanins Suppress Metastasis of Breast Cancer Cells by Targeting RAS/RAF/MAPK Pathway [J].

Chen, Xiang-Yan ;

Zhou, Jie ;

Luo, Li-Ping ;

Han, Bin ;

Li, Fei ;

Chen, Jing-Yao ;

Zhu, Yan-Feng ;

Chen, Wei ;

Yu, Xiao-Ping .

BIOMED RESEARCH INTERNATIONAL, 2015, 2015

[4] The Enhanced Metastatic Potential of Hepatocellular Carcinoma (HCC) Cells with Sorafenib Resistance [J].

Chow, Ariel Ka-Man ;

Ng, Lui ;

Lam, Colin Siu-Chi ;

Wong, Sunny Kit-Man ;

Wan, Timothy Ming-Hun ;

Cheng, Nathan Shiu-Man ;

Yau, Thomas Chung-Cheung ;

Poon, Ronnie Tung-Ping ;

Pang, Roberta Wen-Chi .

PLOS ONE, 2013, 8 (11)

[5] Contributions of Jeffrey Harborne and co-workers to the study of anthocyanins [J].

Cooper-Driver, GA .

PHYTOCHEMISTRY, 2001, 56 (03) :229-236

[6] Chemotherapy Enhances Metastasis Formation via VEGFR-1-Expressing Endothelial Cells [J].

Daenen, Laura G. M. ;

Roodhart, Jeanine M. L. ;

van Amersfoort, Miranda ;

Dehnad, Mantre ;

Roessingh, Wijnand ;

Ulfman, Laurien H. ;

Derksen, Patrick W. B. ;

Voest, Emile E. .

CANCER RESEARCH, 2011, 71 (22) :6976-6985

[7] Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway [J].

Deng, Q. ;

Yu, X. ;

Xiao, L. ;

Hu, Z. ;

Luo, X. ;

Tao, Y. ;

Yang, L. ;

Liu, X. ;

Chen, H. ;

Ding, Z. ;

Feng, T. ;

Tang, Y. ;

Weng, X. ;

Gao, J. ;

Yi, W. ;

Bode, A. M. ;

Dong, Z. ;

Liu, J. ;

Cao, Y. .

CELL DEATH & DISEASE, 2013, 4 :e804-e804

[8] Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer [J].

Eser, Stefan ;

Reiff, Nina ;

Messer, Marlena ;

Seidler, Barbara ;

Gottschalk, Kathleen ;

Dobler, Melanie ;

Hieber, Maren ;

Arbeiter, Andreas ;

Klein, Sabine ;

Kong, Bo ;

Michalski, Christoph W. ;

Schlitter, Anna Melissa ;

Esposito, Irene ;

Kind, Alexander J. ;

Rad, Lena ;

Schnieke, Angelika E. ;

Baccarini, Manuela ;

Alessi, Dario R. ;

Rad, Roland ;

Schmid, Roland M. ;

Schneider, Guenter ;

Saur, Dieter .

CANCER CELL, 2013, 23 (03) :406-420

[9] Role of epithelial to mesenchymal transition in hepatocellular carcinoma [J].

Giannelli, Gianluigi ;

Koudelkova, Petra ;

Dituri, Francesco ;

Mikulits, Wolfgang .

JOURNAL OF HEPATOLOGY, 2016, 65 (04) :798-808

[10] Selective cytotoxicity of a red grape wine flavonoid fraction against MCF-7 cells [J].

Hakimuddin, F ;

Paliyath, G ;

Meckling, K .

BREAST CANCER RESEARCH AND TREATMENT, 2004, 85 (01) :65-79

← 1 2 3 4 →