A review on the effects of PBDEs on thyroid and reproduction systems in fish

被引：85

作者：

Yu, Liqin ^{[1
]}

Han, Zhihua ^{[2
]}

Liu, Chunsheng ^{[1
]}

机构：

[1] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

[2] MEP, Nanjing Inst Environm Sci, Nanjing 210042, Jiangsu, Peoples R China

来源：

GENERAL AND COMPARATIVE ENDOCRINOLOGY | 2015年 / 219卷

基金：

美国国家科学基金会;

关键词：

PBDEs; Thyroid system; Reproductive system; Cross-talk; Fish; POLYBROMINATED DIPHENYL ETHERS; BROMINATED FLAME RETARDANTS; POLYCHLORINATED-BIPHENYLS PCBS; FLOUNDER PLATICHTHYS-FLESUS; AIR-BREATHING CATFISH; PLASMA GROWTH-HORMONE; LONG-TERM EXPOSURE; IN-VITRO; ENDOCRINE DISRUPTION; RAINBOW-TROUT;

D O I：

10.1016/j.ygcen.2014.12.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objective of this review was to summarize and discuss the effects of Polybrominated diphenyl ethers (PBDEs) on thyroid and reproduction systems in fish. We reviewed the evidences and mechanisms for PBDEs-induced thyroid and reproduction disruption, as well as the cross-talk between the two systems in fish. In thyroid disruption, we mainly paid attention to the effects of PBDEs on hypothalamic-pituitary-thyroid (HPT) axis, thyroid hormones (THs) transport and metabolism, thyroid receptors (TRs) and thyroid follicle histology. In reproduction disruption, we focused on the effects of PBDEs on steroid hormone production, expression of genes involved in steroidogenesis, and gonadal development. Despite that there is an interaction between thyroid and reproductive systems in fish, it is still remains unclear that PBDE-induced reproductive impairments are caused by direct effects on hypothalamic-pituitary-gonadal (HPG) functioning or by indirect action through cross-talk between the two systems. Future studies are needed to explore the relationships between reproductive toxicity and thyroid system disruption after PBDEs exposure. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：64 / 73

页数：10

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