Metabolic Profiling of Blood and Urine for Exploring the Functional Role of the Microbiota in Human Health

被引：2
作者：
Diallo, Ana F. [1 ]
Lockwood, Mark B. [2 ]
Maki, Katherine A. [2 ]
Franks, Alexis T. [3 ]
Roy, Abhrarup [3 ]
Jaime-Lara, Rosario [3 ]
Joseph, Paule, V [3 ]
Henderson, Wendy A. [4 ]
Chung, Seon Yoon [5 ]
McGrath, Jacqueline [6 ]
Green, Stefan J. [7 ]
Fink, Anne M. [2 ]
机构：
[1] Virginia Commonwealth Univ, Sch Nursing, Inst Inclus Inquiry & Innovat iCubed Family & Com, Richmond, VA 23284 USA
[2] Univ Illinois, Coll Nursing, Dept Biobehav Hlth Sci, Chicago, IL USA
[3] NIH, Sensory Sci & Metab Unit, Biobehav Branch, Div Intramural Res,Dept Hlth & Human Serv, Bldg 10, Bethesda, MD 20892 USA
[4] NIH, Digest Disorders Unit, Biobehav Branch, Div Intramural Res,Dept Hlth & Human Serv, Bldg 10, Bethesda, MD 20892 USA
[5] Univ Maryland, Sch Nursing, Baltimore, MD 21201 USA
[6] Univ Texas Hlth Sci Ctr San Antonio, Sch Nursing, San Antonio, TX 78229 USA
[7] Univ Illinois, Res Resources Ctr, Sequencing Core, Chicago, IL USA
来源：
BIOLOGICAL RESEARCH FOR NURSING | 2020年 / 22卷 / 04期
基金：
美国国家卫生研究院;
关键词：
blood; cardiovascular; diabetes; trimethylamine n-oxide; metabolomics; microbiome; nursing; urine; TRIMETHYLAMINE-N-OXIDE; GUT; OBESITY;
D O I：
10.1177/1099800420941080
中图分类号：
R47 [护理学];
学科分类号：
1011 ;
摘要：
The quantification of metabolites in blood and urine allows nurses to explore new hypotheses about the microbiome. This review summarizes findings from recent studies with a focus on how the state of the science can influence future nursing research initiatives. Metabolomics can advance nursing research by identifying physiologic/pathophysiologic processes underlying patients' symptoms and can be useful for testing the effects of nursing interventions. To date, metabolomics has been used to study cardiovascular, respiratory, endocrine, autoimmune, and infectious conditions, with research focused on understanding the microbial metabolism of substrates resulting in circulating/excreted biomarkers such as trimethylamine N-oxide. This review provides specific recommendations for the collection of specimens and goals for future studies.
引用
收藏
页码：449 / 457
页数：9
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