Promoter structure of the MxA gene that confers resistance to influenza virus

被引：27
作者：
Nakade, K
Handa, H
Nagata, K
机构：
[1] Dept. of Biomolecular Engineering, Fac. of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama 226
[2] 2nd Pharmaceuticals Laboratory, Yokohama Research Center, Mitsubishi Chemical Corporation, Yokohama
来源：
FEBS LETTERS | 1997年 / 418卷 / 03期
关键词：
MxA; interferon; transcription promoter; influenza virus; reverse transcription-polymerase chain reaction; luciferase assay;
D O I：
10.1016/S0014-5793(97)01372-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The human MxA protein is one of the interferon-inducible proteins that inhibits multiplication of influenza virus and other viruses. To clarify the control mechanism of its expression, we prepared a series of mutant MxA promoters and identified a 30 nucleotides long cis-acting interferon-responsive element by transient transfection assay. Its nucleotide sequence if somewhat similar to that of ISRE (interferon-stimulated response element), suggesting that the regulation of MxA mRNA synthesis is under the control of some ISRE binding factor such as ISGF-3 (interferon-stimulated gene factor-3).
引用
收藏
页码：315 / 318
页数：4
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