Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways

被引：114

作者：

Gomez-Escribano, Juan Pablo ^{[1
]}

Bibb, Mervyn J. ^{[1
]}

机构：

[1] John Innes Ctr, Dept Mol Microbiol, Norwich NR4 7UH, Norfolk, England

来源：

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | 2014年 / 41卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Actinomycete; Heterologous host; Secondary metabolite; Natural product biosynthesis; ENGINEERED BIOSYNTHESIS; POLYKETIDE SYNTHASE; REGULATORY GENE; ANTIBIOTICS; CLONING; A3(2); IDENTIFICATION; REVEALS; ACTIVATION; GENERATION;

D O I：

10.1007/s10295-013-1348-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Heterologous gene expression is one of the main strategies used to access the full biosynthetic potential of actinomycetes, as well as to study the metabolic pathways of natural product biosynthesis and to create unnatural pathways. Streptomyces coelicolor A3(2) is the most studied member of the actinomycetes, bacteria renowned for their prolific capacity to synthesize a wide range of biologically active specialized metabolites. We review here the use of strains of this species for the heterologous production of structurally diverse actinomycete natural products.

引用

页码：425 / 431

页数：7

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