Ruthenium-Catalyzed Carbonylative C-C Coupling in Water by Directed C-H Bond Activation

被引：74

作者：

Tlili, Anis ^{[1
]}

Schranck, Johannes ^{[1
]}

Pospech, Jola ^{[1
]}

Neumann, Helfried ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse, D-18059 Rostock, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 24期

关键词：

C-H activation; homogenous catalysis; ruthenium; synthetic methods; water; DIRECT ORTHO ARYLATION; ARYL CHLORIDES; CROSS-COUPLINGS; HECK REACTION; MOLYBDENUM HEXACARBONYL; PHOSPHINE OXIDES; BENZYL CHLORIDES; BORONIC ACIDS; FUNCTIONALIZATION; BROMIDES;

D O I：

10.1002/anie.201301663

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

First things first: The title reaction of arenes bearing ortho-directing groups (DG) in the presence of a ruthenium catalyst and aryl iodide is presented. The reaction is general for variously substituted aryl iodides to give ketones in moderate to good yields, and water serves as the solvent. The system is highly selective towards the mono-carbonylative arylation by ortho C-H functionalization. cod=cyclo-1,5-octadiene. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6293 / 6297

页数：5

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