Growth Hormone-Releaser Diet Attenuates β-Amyloid(1-42)-Induced Cognitive Impairment via Stimulation of the Insulin-Like Growth Factor (IGF)-1 Receptor in Mice

被引：15

作者：

Shin, Eun-Joo ^{[1
]}

Chae, Jong Seok ^{[1
]}

Park, Seok Joo ^{[1
]}

Kim, Sun Cheol ^{[1
]}

Koo, Kyo Hwan ^{[1
]}

Yamada, Kiyofumi ^{[2
]}

Nabeshima, Toshitaka ^{[3
]}

Kim, Hyoung-Chun ^{[1
]}

机构：

[1] Kangwon Natl Univ, Coll Pharm, Neuropsychopharmacol & Toxicol Program, Chunchon 200701, South Korea

[2] Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Nagoya, Aichi 4668550, Japan

[3] Meijo Univ, Grad Sch Pharmaceut Sci, Dept Chem Pharmacol, Nagoya, Aichi 4688503, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2009年 / 109卷 / 01期

关键词：

growth hormone releaser; beta-amyloid; insulin-like growth factor (IGF)-1 receptor; FACTOR-I; DRUG;

D O I：

10.1254/jphs.08145SC

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We previously demonstrated that the growth hormone (GH)-releaser diet ameliorated beta-amyloid (A beta) (1-42)-induced memory impairment, but the underlying mechanism remained to be characterized. We show here that the GH-releaser diet significantly attenuated A beta(1-42)induced impairment in context-dependent conditioned fear, with a reduction in GH levels and changes in hippocampal acetylcholine, acetylcholinesterase, choline acetyltransferase, insulin-like growth factor (IGF)-1, and IGF-1-receptor activity in mice. JB-1, an IGF-1-receptor antagonist, significantly blocked GH-releaser diet-mediated pharmacological actions. Our results suggest that the GH-releaser diet prevents A beta(1-42)-induced cognitive deficits via stimulation of the hippocampal IGF-1 receptor.

引用

页码：139 / 143

页数：5

共 15 条

[1] SPECTROPHOTOMETRIC ASSAY FOR CHOLINE ACETYLTRANSFERASE [J].