Ketenimines Generated from Ynamides: Versatile Building Blocks for Nitrogen-Containing Scaffolds

Using ynamides as readily available starting materials, a single step can generate highly reactive ketenimines, which can then undergo a variety of transformations. The choice of the method for generating the ketenimine dictates the outcome of the reaction that can, moreover, be precisely steered through minor variations of the starting material. This Concept gives an overview of the different existing methodologies for this objective, show-casing the diverse nitrogen-containing frameworks that can be obtained by this highly versatile strategy.