Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway

被引：41

作者：

Rodriguez-Araujo, Gerardo ^{[1
]}

Nakagami, Hironori ^{[1
,2
]}

Hayashi, Hiroki ^{[1
]}

Mori, Masaki ^{[1
]}

Shiuchi, Tetsuya ^{[3
]}

Minokoshi, Yasuhiko ^{[3
]}

Nakaoka, Yoshikazu ^{[5
]}

Takami, Yoichi ^{[1
]}

Komuro, Issei ^{[5
]}

Morishita, Ryuichi ^{[4
]}

Kaneda, Yasufumi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Div Gene Therapy Sci, Suita, Osaka 5650871, Japan

[2] Osaka Univ, United Grad Sch Child Dev, Div Vasc Med & Epigenet, Suita, Osaka 5650871, Japan

[3] Natl Inst Physiol Sci, Dept Dev Physiol, Div Endocrinol & Metab, Okazaki, Aichi 444, Japan

[4] Osaka Univ, Grad Sch Med, Dept Clin Gene Therapy, Suita, Osaka 5650871, Japan

[5] Osaka Univ, Grad Sch Med, Dept Cardiovasc Med, Suita, Osaka 5650871, Japan

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2013年 / 70卷 / 06期

关键词：

Glucose uptake; Glucose utilization; Alpha-synuclein; Gab1; Adipocytes; Myocytes; SKELETAL-MUSCLE; PROTEIN; FAMILY; MICE; ACTIVATION; LEPTIN; STIMULATION; RECEPTORS; REGULATOR; AMPK;

D O I：

10.1007/s00018-012-1198-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin is the main glucoregulator that promotes the uptake of glucose by tissues and the subsequent utilization of glucose as an energy source. In this paper, we describe a novel glucoregulator, the alpha-synuclein (SNCA) protein, that has previously been linked to Parkinson's disease. Treatment with recombinant SNCA promotes glucose uptake in vitro in preadipocytes and in vivo in the adipose tissues and skeletal muscles of mice through the LPAR2/Gab1/PI3K/Akt pathway; these effects occur independently of the insulin receptor. This function of SNCA represents a new mechanistic insight that creates novel avenues of research with respect to the process of glucose regulation.

引用

页码：1123 / 1133

页数：11

共 41 条

[21] Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing
Jiang, ZY
Zhou, QL
Coleman, KA
Chouinard, M
Boese, Q
Czech, MP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) : 7569 - 7574
[22] Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress
Kurz, Alexander
Rabbani, Naila
Walter, Michael
Bonin, Michael
Thornalley, Paul
Auburger, Georg
Gispert, Suzana
[J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2011, 68 (04) : 721 - 733
[23] The EGF-TM7 family: a postgenomic view
Kwakkenbos, MJ
Kop, EN
Stacey, M
Matmati, M
Gordon, S
Lin, HH
Hamann, J
[J]. IMMUNOGENETICS, 2004, 55 (10) : 655 - 666
[24] Orphan G protein-coupled receptors: targets for new therapeutic interventions
Lin, SH
Civelli, O
[J]. ANNALS OF MEDICINE, 2004, 36 (03) : 204 - 214
[25] Glycogen Synthase Kinase 3β Is a Novel Regulator of High Glucose- and High Insulin-induced Extracellular Matrix Protein Synthesis in Renal Proximal Tubular Epithelial Cells
Mariappan, Meenalakshmi M.
Shetty, Megan
Sataranatarajan, Kavithalakshmi
Choudhury, Goutam Ghosh
Kasinath, Balakuntalam S.
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (45) : 30566 - 30575
[26] AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain
Mîinea, CP
Sano, H
Kane, S
Sano, E
Fukuda, M
Peränen, J
Lane, WS
Lienhard, GE
[J]. BIOCHEMICAL JOURNAL, 2005, 391 : 87 - 93
[27] AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Minokoshi, Y
Alquier, T
Furukawa, N
Kim, YB
Lee, A
Xue, BZ
Mu, J
Foufelle, F
Ferré, P
Birnbaum, MJ
Stuck, BJ
Kahn, BB
[J]. NATURE, 2004, 428 (6982) : 569 - 574
[28] AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
O'Neill, Hayley M.
Maarbjerg, Stine J.
Crane, Justin D.
Jeppesen, Jacob
Jorgensen, Sebastian B.
Schertzer, Jonathan D.
Shyroka, Olga
Kiens, Bente
van Denderen, Bryce J.
Tarnopolsky, Mark A.
Kemp, Bruce E.
Richter, Erik A.
Steinberg, Gregory R.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (38) : 16092 - 16097
[29] Ki16425, a subtype-selective antagonist for EDG-Family lysophosphatidic acid receptors
Ohta, H
Sato, K
Murata, N
Damirin, A
Malchinkhuu, E
Kon, J
Kimura, T
Tobo, M
Yamazaki, Y
Watanabe, T
Yagi, M
Sato, M
Suzuki, R
Murooka, H
Sakai, T
Nishitoba, T
Im, DS
Nochi, H
Tamoto, K
Tomura, H
Okajima, F
[J]. MOLECULAR PHARMACOLOGY, 2003, 64 (04) : 994 - 1005
[30] Evidence that α-synuclein functions as a negative regulator of Ca+ +-dependent α-granule release from human platelets
Park, SM
Jung, HY
Kim, HO
Rhim, H
Paik, SR
Chung, KC
Park, JH
Kim, J
[J]. BLOOD, 2002, 100 (07) : 2506 - 2514

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