Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway

被引：41
作者：
Rodriguez-Araujo, Gerardo [1 ]
Nakagami, Hironori [1 ,2 ]
Hayashi, Hiroki [1 ]
Mori, Masaki [1 ]
Shiuchi, Tetsuya [3 ]
Minokoshi, Yasuhiko [3 ]
Nakaoka, Yoshikazu [5 ]
Takami, Yoichi [1 ]
Komuro, Issei [5 ]
Morishita, Ryuichi [4 ]
Kaneda, Yasufumi [1 ]
机构：
[1] Osaka Univ, Grad Sch Med, Div Gene Therapy Sci, Suita, Osaka 5650871, Japan
[2] Osaka Univ, United Grad Sch Child Dev, Div Vasc Med & Epigenet, Suita, Osaka 5650871, Japan
[3] Natl Inst Physiol Sci, Dept Dev Physiol, Div Endocrinol & Metab, Okazaki, Aichi 444, Japan
[4] Osaka Univ, Grad Sch Med, Dept Clin Gene Therapy, Suita, Osaka 5650871, Japan
[5] Osaka Univ, Grad Sch Med, Dept Cardiovasc Med, Suita, Osaka 5650871, Japan
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2013年 / 70卷 / 06期
关键词：
Glucose uptake; Glucose utilization; Alpha-synuclein; Gab1; Adipocytes; Myocytes; SKELETAL-MUSCLE; PROTEIN; FAMILY; MICE; ACTIVATION; LEPTIN; STIMULATION; RECEPTORS; REGULATOR; AMPK;
D O I：
10.1007/s00018-012-1198-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Insulin is the main glucoregulator that promotes the uptake of glucose by tissues and the subsequent utilization of glucose as an energy source. In this paper, we describe a novel glucoregulator, the alpha-synuclein (SNCA) protein, that has previously been linked to Parkinson's disease. Treatment with recombinant SNCA promotes glucose uptake in vitro in preadipocytes and in vivo in the adipose tissues and skeletal muscles of mice through the LPAR2/Gab1/PI3K/Akt pathway; these effects occur independently of the insulin receptor. This function of SNCA represents a new mechanistic insight that creates novel avenues of research with respect to the process of glucose regulation.
引用
收藏
页码：1123 / 1133
页数：11
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