P2X7 receptors in cerebral ischemia

被引：20

作者：

Bai, Hui-Yu ^{[1
]}

Li, Ai-Ping ^{[1
]}

机构：

[1] Dalian Med Univ, Dept Physiol, Dalian 116044, Peoples R China

来源：

NEUROSCIENCE BULLETIN | 2013年 / 29卷 / 03期

关键词：

P2X(7) receptor; cerebral ischemia; neurotoxicity; calcium overload; neuroinflammation; neurotransmitter; receptor antagonist; IN-VITRO ISCHEMIA; MICROGLIAL CELLS; RAT HIPPOCAMPUS; GLUCOSE DEPRIVATION; OXYGEN/GLUCOSE DEPRIVATION; PURINERGIC RECEPTORS; CORTICAL-NEURONS; PLASMA-MEMBRANE; BRAIN ISCHEMIA; ATP;

D O I：

10.1007/s12264-013-1338-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cerebral ischemia is one of the most common diseases resulting in death and disability in aged people. It leads immediately to rapid energy failure, ATP depletion, and ionic imbalance, which increase extracellular ATP levels and accordingly activate P2X(7) receptors. These receptors are ATP-gated cation channels and widely distributed in nerve cells, especially in the immunocompetent cells of the brain. Currently, interest in the roles of P2X(7) receptors in ischemic brain injury is growing. In this review, we discuss recent research progress on the actions of P2X(7) receptors, their possible mechanisms in cerebral ischemia, and the potential therapeutic value of P2X(7) receptor antagonists which may provide a new target both for clinical and for research purposes.

引用

页码：390 / 398

页数：9

共 65 条

[1] Purinergic signalling in the nervous system: an overview [J].

Abbracchio, Maria P. ;

Burnstock, Geoffrey ;

Verkhratsky, Alexei ;

Zimmermann, Herbert .

TRENDS IN NEUROSCIENCES, 2009, 32 (01) :19-29

[2] P2X7 receptor: Death or life? [J].

Adinolfi E. ;

Pizzirani C. ;

Idzko M. ;

Panther E. ;

Norgauer J. ;

Di Virgilio F. ;

Ferrari D. .

Purinergic Signalling, 2005, 1 (3) :219-227

[3] Functional evidence for presynaptic P2X7 receptors in adult rat cerebrocortical nerve terminals [J].

Alloisio, Susanna ;

Cervetto, Chiara ;

Passalacqua, Mario ;

Barbieri, Raffaella ;

Maura, Guido ;

Nobile, Mario ;

Marcoli, Manuela .

FEBS LETTERS, 2008, 582 (28) :3948-3953

[4] Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons [J].

Anderson, CM ;

Nedergaard, M .

TRENDS IN NEUROSCIENCES, 2006, 29 (05) :257-262

[5] P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia [J].

Arbeloa, Joana ;

Perez-Samartin, Alberto ;

Gottlieb, Miroslav ;

Matute, Carlos .

NEUROBIOLOGY OF DISEASE, 2012, 45 (03) :954-961

[6] Purinergic receptors - An ATP-gated ion channel at the cell nucleus [J].

Atkinson, L ;

Milligan, CJ ;

Buckley, NJ ;

Deuchars, J .

NATURE, 2002, 420 (6911) :42-42

[7] Ca2+ signals and neuronal death in brain ischemia [J].

Bano, Daniele ;

Nicotera, Pierluigi .

STROKE, 2007, 38 (02) :674-676

[8] Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor-independent mechanisms [J].

Beigi, RD ;

Kertesy, SB ;

Aquilina, G ;

Dubyak, GR .

BRITISH JOURNAL OF PHARMACOLOGY, 2003, 140 (03) :507-519

[9] Astrocyte-derived ATP induces vesicle shedding and IL-1β release from microglia [J].

Bianco, F ;

Pravettoni, E ;

Colombo, A ;

Schenk, U ;

Möller, T ;

Matteoli, M ;

Verderio, C .

JOURNAL OF IMMUNOLOGY, 2005, 174 (11) :7268-7277

[10] Purinergic receptors on microglial cells:: functional expression in acute brain slices and modulation of microglial activation in vitro [J].

Boucsein, C ;

Zacharias, R ;

Färber, K ;

Pavlovic, S ;

Hanisch, UK ;

Kettenmann, H .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 17 (11) :2267-2276

← 1 2 3 4 5 6 7 →