Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

被引：25

作者：

Fang, Yu ^{[1
,2
]}

Chen, Xiaoxin ^{[1
,3
]}

Bajpai, Manisha ^{[4
]}

Verma, Amit ^{[4
]}

Das, Kiron M. ^{[4
]}

Souza, Rhonda F. ^{[5
,6
]}

Garman, Katherine S. ^{[7
]}

Donohoe, Claire L. ^{[8
,9
]}

O'Farrell, Naoimh J. ^{[8
,9
]}

Reynolds, John V. ^{[8
,9
]}

Dvorak, Katerina ^{[10
]}

机构：

[1] N Carolina Cent Univ, JLC BBRI, Canc Res Program, Durham, NC 27707 USA

[2] Cent S Univ, Xiangya Hosp 2, Dept Cardiovasc & Thorac Surg, Changsha, Hunan, Peoples R China

[3] Univ N Carolina, Dept Med, Ctr Esophageal Dis & Swallowing, Div Gastroenterol & Hepatol, Chapel Hill, NC USA

[4] UMDNJ RWJMS, Dept Med, New Brunswick, NJ USA

[5] Univ Texas SW Med Ctr Dallas, Dept Med, Dallas, TX 75390 USA

[6] VA North Texas Hlth Care Syst, Dallas, TX USA

[7] Duke Univ, Dept Med, Durham, NC USA

[8] Univ Dublin Trinity Coll, Dublin 2, Ireland

[9] St James Hosp, Trin Ctr Hlth Sci, Dublin 8, Ireland

[10] Univ Arizona, Arizona Canc Ctr, Dept Cellular & Mol Med, Tucson, AZ USA

来源：

11TH OESO WORLD CONFERENCE: REFLUX DISEASE | 2013年 / 1300卷

关键词：

Barrett's esophagus; esophageal adenocarcinoma; autophagy; obesity; DNA methylation; WHITE ADIPOSE-TISSUE; MICRORNA EXPRESSION; EPITHELIAL-CELLS; PREMALIGNANT LESION; DEOXYCHOLIC-ACID; DNA METHYLATION; CANCER; MODEL; PROGRESSION; GENE;

D O I：

10.1111/nyas.12249

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.

引用

页码：187 / 199

页数：13

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