Brain calcifications induce neurological dysfunction that can be reversed by a bone drug

被引:32
作者
Loeb, JA
Sohrab, SA
Huq, M
Fuerst, DR
机构
[1] Wayne State Univ, Sch Med, Dept Neurol, Detroit, MI 48201 USA
[2] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA
[3] Wayne State Univ, Sch Med, Dept Pediat, Detroit, MI 48201 USA
关键词
calcification; epilepsy; headache; bisphosphonate; etidronatc; cavernous hemangioma; neurocysticercosis;
D O I
10.1016/j.jns.2005.11.033
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Perivascular calcifications within the brain Conn in response to a variety of insults. While considered by many to be benign, these calcium phosphate deposits or "brain stones" can become large and are associated with neurological symptoms that range from seizures to parkinsonian symptoms. Here we hypothesize that file high concentrations or calcium in these deposits produce reversible, toxic effects on neurons that can be overcome with "bone" drugs that chelate solid phase calcium phosphates. We present preliminary findings that suggest a direct association between progressive neurological symptoms and brain calcification and the symptomatic improvement of seizures, headaches, and parkinsonian symptoms in patients treated with the bisphosphonate drug disodium etidronate, normally used to treat bone diseases. Future, longitudinal epidemiological studies and randomized trials will be needed to determine the true relationship between brain stories and neurological disorders as well as the utility of bisphosphonates in their prevention and treatment. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:77 / 81
页数:5
相关论文
共 15 条
[11]   Calcific neurocysticercosis and epileptogenesis [J].
Nash, TE ;
Del Brutto, H ;
Butman, JA ;
Corona, T ;
Delgado-Escueta, A ;
Duron, RM ;
Evans, CAW ;
Gilman, RH ;
Gonzalez, AE ;
Loeb, JA ;
Medina, MT ;
Pietsch-Escueta, S ;
Pretell, EJ ;
Takayanagui, OM ;
Theodore, W ;
Tsang, VCW ;
Garcia, HH .
NEUROLOGY, 2004, 62 (11) :1934-1938
[12]   Molecular mechanisms of calcium-dependent excitotoxicity [J].
Sattler, R ;
Tymianski, M .
JOURNAL OF MOLECULAR MEDICINE-JMM, 2000, 78 (01) :3-13
[13]   CHEMICAL COMPOSITION OF IDIOPATHIC NON-ARTERIOSCLEROTIC CEREBRAL CALCIFICATIONS [J].
SMEYERSVERBEKE, J ;
MICHOTTE, Y ;
PELSMAECKERS, J ;
LOWENTHAL, A ;
MASSART, DL ;
DEKEGEL, D ;
KARCHER, D .
NEUROLOGY, 1975, 25 (01) :48-57
[14]   Cognitive performance of patients with mesial temporal lobe epilepsy and incidental calcified neurocysticercosis [J].
Terra-Bustamante, VC ;
Coimbra, ÉR ;
Rezek, KO ;
Escorsi-Rosset, SR ;
Guarnieri, R ;
Dalmagro, CL ;
Inuzuka, LM ;
Bianchin, MM ;
Wichert-Ana, L ;
Alexandre, V ;
Takayanagui, OM ;
Araújo, D ;
dos Santos, AC ;
Carlotti, CG ;
Walz, R ;
Markowitsch, HJ ;
Sakamoto, AC .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2005, 76 (08) :1080-1083
[15]  
Thussu A, 2002, NEUROL INDIA, V50, P141