Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments

被引：333
作者：
George, Paul M. [1 ,2 ,3 ]
Steinberg, Gary K. [1 ,2 ,3 ]
机构：
[1] Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Stanford Stroke Ctr, Stanford, CA 94305 USA
来源：
NEURON | 2015年 / 87卷 / 02期
关键词：
NEURAL STEM-CELLS; TRANSCRANIAL MAGNETIC STIMULATION; MARROW MONONUCLEAR-CELLS; PROMOTES FUNCTIONAL RECOVERY; FOCAL CEREBRAL-ISCHEMIA; HUMAN NEURONAL CELLS; BLOOD-BRAIN-BARRIER; IN-VITRO; CORTICAL STIMULATION; NEUROTROPHIC FACTOR;
D O I：
10.1016/j.neuron.2015.05.041
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Stroke remains a leading cause of death and disability in the world. Over the past few decades our understanding of the pathophysiology of stroke has increased, but greater insight is required to advance the field of stroke recovery. Clinical treatments have improved in the acute time window, but long-term therapeutics remain limited. Complex neural circuits damaged by ischemia make restoration of function after stroke difficult. New therapeutic approaches, including cell transplantation or stimulation, focus on reestablishing these circuits through multiple mechanisms to improve circuit plasticity and remodeling. Other research targets intact networks to compensate for damaged regions. This review highlights several important mechanisms of stroke injury and describes emerging therapies aimed at improving clinical outcomes.
引用
收藏
页码：297 / 309
页数：13
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