Rapid multiexposure in vivo brain imaging system using vertical cavity surface emitting lasers as a light source

被引：16

作者：

Atchia, Yaaseen ^{[1
,2
]}

Levy, Hart ^{[1
,2
]}

Dufour, Suzie ^{[1
,2
]}

Levi, Ofer ^{[1
,2
]}

机构：

[1] Univ Toronto, Edward S Rogers Sr Dept Elect & Comp Engn, Toronto, ON M5S 3G4, Canada

[2] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada

来源：

APPLIED OPTICS | 2013年 / 52卷 / 07期

基金：

加拿大自然科学与工程研究理事会;

关键词：

BLOOD OXYGENATION; SPECKLE; FLOW; DYNAMICS;

D O I：

10.1364/AO.52.000C64

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate an imaging technique implementing vertical cavity lasers with extremely low transient times for a greatly simplified realization of a multiexposure laser speckle contrast imaging system. Data from multiexposure laser speckle imaging was observed to more closely agree with absolute velocity measurements using time of flight technique, when compared to long-exposure laser speckle imaging. Furthermore, additional depth information of the vasculature morphology was inferred by accounting for the change in the static scattering from tissue above vessels with respect to the total scattering from blood flow and tissue. (C) 2013 Optical Society of America

引用

页码：C64 / C71

页数：8

共 21 条

[1]

Atchia Y., 2012, APPL IND OPTICS SPEC

[2] Laser speckle contrast imaging in biomedical optics [J].

Boas, David A. ;

Dunn, Andrew K. .

JOURNAL OF BIOMEDICAL OPTICS, 2010, 15 (01)

[3] Ultra-fast multispectral optical imaging of cortical oxygenation, blood flow, and intracellular calcium dynamics [J].

Bouchard, Matthew B. ;

Chen, Brenda R. ;

Burgess, Sean A. ;

Hillman, Elizabeth M. C. .

OPTICS EXPRESS, 2009, 17 (18) :15670-15678

[4] Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity [J].

Devor, A ;

Ulbert, I ;

Dunn, AK ;

Narayanan, SN ;

Jones, SR ;

Andermann, ML ;

Boas, DA ;

Dale, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (10) :3822-3827

[5] Exploring brain function with magnetic resonance imaging [J].

Di Salle, F ;

Formisano, E ;

Linden, DEJ ;

Goebel, R ;

Bonavita, S ;

Pepino, A ;

Smaltino, F ;

Tedeschi, G .

EUROPEAN JOURNAL OF RADIOLOGY, 1999, 30 (02) :84-94

[6] What is the proper statistical model for laser speckle flowmetry? [J].

Duncan, Donald D. ;

Kirkpatrick, Sean J. ;

Gladish, James C. .

COMPLEX DYNAMICS AND FLUCTUATIONS IN BIOMEDICAL PHOTONICS V, 2008, 6855

[7] Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation [J].

Dunn, AK ;

Devor, A ;

Bolay, H ;

Andermann, ML ;

Moskowitz, MA ;

Dale, AM ;

Boas, DA .

OPTICS LETTERS, 2003, 28 (01) :28-30

[8] FLOW VISUALIZATION BY MEANS OF SINGLE-EXPOSURE SPECKLE PHOTOGRAPHY [J].

FERCHER, AF ;

BRIERS, JD .

OPTICS COMMUNICATIONS, 1981, 37 (05) :326-330

[9]

Ghosh KK, 2011, NAT METHODS, V8, P871, DOI [10.1038/NMETH.1694, 10.1038/nmeth.1694]

[10] SOME FUNDAMENTAL PROPERTIES OF SPECKLE [J].

GOODMAN, JW .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA, 1976, 66 (11) :1145-1150

← 1 2 3 →