Characterization of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant Virus Form in Guizhou, China

被引：0
作者：
Wu, Li [1 ]
Huang, Ling [1 ]
Zhang, Wangming [2 ]
Liu, Jinhe [3 ]
Kong, Yihua [4 ]
机构：
[1] Peoples Hosp Zunyi City Bo Zhou Dist, Zunyi, Peoples R China
[2] Guiyang Univ Chinese Med, Affiliated Hosp 1, Guiyang, Guizhou, Peoples R China
[3] Guizhou Med Univ, Tissue Engn & Stem Cell Res Ctr, Guiyang, Guizhou, Peoples R China
[4] Guizhou Med Univ, Affiliated Hosp 2, Guiyang 556000, Guizhou, Peoples R China
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2019年 / 35卷 / 07期
关键词：
CRF01_AE/CRF07_BC; HIV; China; LENGTH GENOME SEQUENCE; CIRCULATING RECOMBINANT; EPIDEMIC; MEN; SEX; CRF01-AE; HISTORY; STRAIN;
D O I：
10.1089/aid.2019.0010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We identified a novel CRF01_AE and 07_BC HIV-1 recombinant form in Guizhou province in southwest China. The phylogenetic analysis of the near full-length sequence reveals that it was divided into five segments by four breakpoints, and the CRF01_AE regions of the recombinant were clustered with subcluster 4 lineage of CRF01_AE, which mainly circulated among men who have sex with men (MSM) in China. The CRF07_BC regions of the recombinant were clustered with CRF07_BC lineage, which circulated among Chinese MSM. This is the first detection of a novel HIV-1 second-generation recombinant form (CRF07_BC/CRF01_AE) in Guizhou, which shows the increasing significance of heterosexual transmission contributing to the complexity of the HIV-1 epidemic in southwest China, and more effort measures should be taken to monitor the genetic evolution of HIV-1 strains and prevent HIV-1 transmissions.
引用
收藏
页码：664 / 667
页数：4
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