Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

被引：35
作者：
Konger, Raymond L. [1 ,2 ]
Marathe, Gopal K. [3 ]
Yao, Yongxue [2 ,4 ]
Zhang, Qiwei [2 ,4 ]
Travers, Jeffrey B. [2 ,4 ,5 ,6 ]
机构：
[1] Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN 46202 USA
[2] Indiana Univ, Dept Dermatol, Indianapolis, IN 46202 USA
[3] Univ Mysore, Dept Biochem, Mysore 570006, Karnataka, India
[4] Indiana Univ, HB Wells Ctr Pediat Res, Indianapolis, IN 46202 USA
[5] Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA
[6] Richard L Roudebush VA Med Ctr, Indianapolis, IN 46202 USA
来源：
PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2008年 / 87卷 / 1-4期
关键词：
Oxidation; Ultraviolet rays; Peroxisome proliferator-activated receptor gamma; Platelet-activating factor receptor; Glycerophosphoscholines;
D O I：
10.1016/j.prostaglandins.2008.04.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation. (C) 2008 Elsevier Inc. All rights reserved.
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收藏
页码：1 / 8
页数：8
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