Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

被引：35

作者：

Konger, Raymond L. ^{[1
,2
]}

Marathe, Gopal K. ^{[3
]}

Yao, Yongxue ^{[2
,4
]}

Zhang, Qiwei ^{[2
,4
]}

Travers, Jeffrey B. ^{[2
,4
,5
,6
]}

机构：

[1] Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Dept Dermatol, Indianapolis, IN 46202 USA

[3] Univ Mysore, Dept Biochem, Mysore 570006, Karnataka, India

[4] Indiana Univ, HB Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

[5] Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA

[6] Richard L Roudebush VA Med Ctr, Indianapolis, IN 46202 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2008年 / 87卷 / 1-4期

关键词：

Oxidation; Ultraviolet rays; Peroxisome proliferator-activated receptor gamma; Platelet-activating factor receptor; Glycerophosphoscholines;

D O I：

10.1016/j.prostaglandins.2008.04.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1 / 8

页数：8

共 101 条

[41] Biology of PPARγ in cancer:: A critical review on existing lacunae [J].

Krishnan, Anand ;

Nair, S. Asha ;

Pillai, M. Radhakrishna .

CURRENT MOLECULAR MEDICINE, 2007, 7 (06) :532-540

[42] Peroxisome proliferator-activated receptors in cutaneous biology [J].

Kuenzli, S ;

Saurat, JH .

BRITISH JOURNAL OF DERMATOLOGY, 2003, 149 (02) :229-236

[43]

Kuenzli Stephane, 2004, Curr Drug Targets Inflamm Allergy, V3, P205, DOI 10.2174/1568010043343976

[44] Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice [J].

Kuwamoto, K ;

Miyauchi-Hashimoto, H ;

Tanaka, K ;

Eguchi, N ;

Inui, T ;

Urade, Y ;

Horio, T .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 114 (02) :241-246

[45] AN ANTIDIABETIC THIAZOLIDINEDIONE IS A HIGH-AFFINITY LIGAND FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA(PPAR-GAMMA) [J].

LEHMANN, JM ;

MOORE, LB ;

SMITHOLIVER, TA ;

WILKISON, WO ;

WILLSON, TM ;

KLIEWER, SA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (22) :12953-12956

[46] Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking [J].

Lehr, HA ;

Weyrich, AS ;

Saetzler, RK ;

Jurek, A ;

Arfors, KE ;

Zimmerman, GA ;

Prescott, SM ;

McIntyre, TM .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (10) :2358-2364

[47] 15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells [J].

Lim, Hyun-Joung ;

Lee, Kuy-Sook ;

Lee, Seahyoung ;

Park, Jin-Hee ;

Choi, Hye-Eun ;

Go, Sang Hee ;

Kwak, Hyun-Jeong ;

Park, Hyun-Young .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2007, 223 (01) :20-27

[48] LIPID OXIDATION - BIOLOGIC EFFECTS AND ANTIOXIDANTS - A REVIEW [J].

LOGANI, MK ;

DAVIES, RE .

LIPIDS, 1980, 15 (06) :485-495

[49] Peroxisome-proliferator-activated receptor (PPAR)-γ activation stimulates keratinocyte differentiation [J].

Mao-Qiang, M ;

Fowler, AJ ;

Schmuth, M ;

Lau, P ;

Chang, S ;

Brown, BE ;

Moser, AH ;

Michalik, L ;

Desvergne, B ;

Wahli, W ;

Li, M ;

Metzger, D ;

Chambon, PH ;

Elias, PM ;

Feingold, KR .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (02) :305-312

[50] Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage [J].

Marathe, GK ;

Johnson, C ;

Billings, SD ;

Southall, MD ;

Pei, Y ;

Spandau, D ;

Murphy, RC ;

Zimmerman, GA ;

McIntyre, TM ;

Travers, JB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (42) :35448-35457

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