Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

被引：34

作者：

Konger, Raymond L. ^{[1
,2
]}

Marathe, Gopal K. ^{[3
]}

Yao, Yongxue ^{[2
,4
]}

Zhang, Qiwei ^{[2
,4
]}

Travers, Jeffrey B. ^{[2
,4
,5
,6
]}

机构：

[1] Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Dept Dermatol, Indianapolis, IN 46202 USA

[3] Univ Mysore, Dept Biochem, Mysore 570006, Karnataka, India

[4] Indiana Univ, HB Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

[5] Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA

[6] Richard L Roudebush VA Med Ctr, Indianapolis, IN 46202 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2008年 / 87卷 / 1-4期

关键词：

Oxidation; Ultraviolet rays; Peroxisome proliferator-activated receptor gamma; Platelet-activating factor receptor; Glycerophosphoscholines;

D O I：

10.1016/j.prostaglandins.2008.04.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1 / 8

页数：8

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