Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

被引：35

作者：

Konger, Raymond L. ^{[1
,2
]}

Marathe, Gopal K. ^{[3
]}

Yao, Yongxue ^{[2
,4
]}

Zhang, Qiwei ^{[2
,4
]}

Travers, Jeffrey B. ^{[2
,4
,5
,6
]}

机构：

[1] Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Dept Dermatol, Indianapolis, IN 46202 USA

[3] Univ Mysore, Dept Biochem, Mysore 570006, Karnataka, India

[4] Indiana Univ, HB Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

[5] Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA

[6] Richard L Roudebush VA Med Ctr, Indianapolis, IN 46202 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2008年 / 87卷 / 1-4期

关键词：

Oxidation; Ultraviolet rays; Peroxisome proliferator-activated receptor gamma; Platelet-activating factor receptor; Glycerophosphoscholines;

D O I：

10.1016/j.prostaglandins.2008.04.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1 / 8

页数：8

共 101 条

[21] CHEMISTRY OF FREE-RADICAL AND SINGLET OXIDATION OF LIPIDS [J].

FRANKEL, EN .

PROGRESS IN LIPID RESEARCH, 1984, 23 (04) :197-221

[22] Peroxisome proliferator-activated receptors and their relevance to dermatology [J].

Friedmann, PS ;

Cooper, HL ;

Healy, E .

ACTA DERMATO-VENEREOLOGICA, 2005, 85 (03) :194-202

[23] Impact of oxidized low density lipoprotein on vascular cells [J].

Galle, J ;

Hansen-Hagge, T ;

Wanner, C ;

Seibold, S .

ATHEROSCLEROSIS, 2006, 185 (02) :219-226

[24] OXYGEN RADICAL CHEMISTRY OF POLY-UNSATURATED FATTY-ACIDS [J].

GARDNER, HW .

FREE RADICAL BIOLOGY AND MEDICINE, 1989, 7 (01) :65-86

[25]

Genolet Raphael, 2004, Current Drug Targets - Inflammation and Allergy, V3, P361, DOI 10.2174/1568010042634578

[26] NOVEL EFFECTS OF 1-0-HEXADECYL-2-ACYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE MEDIATORS ON HUMAN-LEUKOCYTE FUNCTION - DELINEATION OF THE SPECIFIC ROLES OF THE ACYL SUBSTITUENTS [J].

GOETZL, EJ ;

DERIAN, CK ;

TAUBER, AI ;

VALONE, FH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 94 (03) :881-888

[27] Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells [J].

Gruber, Florian ;

Oskolkova, Olga ;

Leitner, Alexander ;

Mildner, Michael ;

Mlitz, Veronika ;

Lengauer, Barbara ;

Kadl, Alexandra ;

Mrass, Paul ;

Kroenke, Gerhard ;

Binder, Bernd R. ;

Bochkov, Valery N. ;

Leitinger, Norbert ;

Tschachler, Erwin .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (23) :16934-16941

[28] 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation [J].

Han, Hoon ;

Shin, Sung-Won ;

Seo, Chi-Yeon ;

Kwon, Hyuk-Chan ;

Han, Jin-Yeong ;

Kim, In-Hoo ;

Kwak, Jong-Young ;

Park, Joo-In .

APOPTOSIS, 2007, 12 (11) :2101-2114

[29] The effect of PPAR ligands on UV-γ or chemically-induced carcinogenesis in mouse skin [J].

He, GB ;

Muga, S ;

Thuillier, P ;

Lubet, RA ;

Fischer, SM .

MOLECULAR CARCINOGENESIS, 2005, 43 (04) :198-206

[30] PPARγ in human and mouse physiology [J].

Heikkinen, Sami ;

Auwerx, Johan ;

Argmann, Carmen A. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2007, 1771 (08) :999-1013

← 1 2 3 4 5 6 7 8 9 10 →