Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

被引：34
作者：
Konger, Raymond L. [1 ,2 ]
Marathe, Gopal K. [3 ]
Yao, Yongxue [2 ,4 ]
Zhang, Qiwei [2 ,4 ]
Travers, Jeffrey B. [2 ,4 ,5 ,6 ]
机构：
[1] Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN 46202 USA
[2] Indiana Univ, Dept Dermatol, Indianapolis, IN 46202 USA
[3] Univ Mysore, Dept Biochem, Mysore 570006, Karnataka, India
[4] Indiana Univ, HB Wells Ctr Pediat Res, Indianapolis, IN 46202 USA
[5] Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA
[6] Richard L Roudebush VA Med Ctr, Indianapolis, IN 46202 USA
来源：
PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2008年 / 87卷 / 1-4期
关键词：
Oxidation; Ultraviolet rays; Peroxisome proliferator-activated receptor gamma; Platelet-activating factor receptor; Glycerophosphoscholines;
D O I：
10.1016/j.prostaglandins.2008.04.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：1 / 8
页数：8
相关论文
共 101 条
  • [1] Acute keratinocyte damage stimulates platelet-activating factor production
    Alappatt, C
    Johnson, CA
    Clay, KL
    Travers, JB
    [J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 2000, 292 (05) : 256 - 259
  • [2] Fatty acid transduction of nitric oxide signaling - Multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands
    Baker, PRS
    Lin, YM
    Schopfer, FJ
    Woodcock, SR
    Groeger, AL
    Batthyany, C
    Sweeney, S
    Long, MH
    Iles, KE
    Baker, LMS
    Branchaud, BP
    Chen, YQE
    Freeman, BA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (51) : 42464 - 42475
  • [3] Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line
    Barber, LA
    Spandau, DF
    Rathman, SC
    Murphy, RC
    Johnson, CA
    Kelley, SW
    Hurwitz, SA
    Travers, JB
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (30) : 18891 - 18897
  • [4] Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair
    Bartsch, Helmut
    Nair, Jagadeesan
    [J]. LANGENBECKS ARCHIVES OF SURGERY, 2006, 391 (05) : 499 - 510
  • [5] BLACK HS, 1985, CANCER RES, V45, P6254
  • [6] BLACK HS, 1987, FASEB J, V46, P1901
  • [7] UVB irradiation modulates systemic immune responses by affecting cytokine production of antigen-presenting cells
    Boonstra, A
    van Oudenaren, A
    Barendregt, B
    An, LG
    Leenen, PJM
    Savelkoul, HFJ
    [J]. INTERNATIONAL IMMUNOLOGY, 2000, 12 (11) : 1531 - 1538
  • [8] Peroxisome proliferator-activated receptor-γ-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis
    Bright, JJ
    Natarajan, C
    Muthian, G
    Barak, Y
    Evans, RM
    [J]. JOURNAL OF IMMUNOLOGY, 2003, 171 (11) : 5743 - 5750
  • [9] n-3 and n-6 polyunsaturated fatty acids induce the expression of COX-2 via PPARγ activation in human keratinocyte HaCaT cells
    Chene, Gerald
    Dubourdeau, Marc
    Balard, Patricia
    Escoubet-Lozach, Laure
    Orfila, Claudine
    Berry, Antoine
    Bernad, Jose
    Aries, Marie-Francoise
    Charveron, Marie
    Pipy, Bernard
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2007, 1771 (05): : 576 - 589
  • [10] Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4
    Chun, Kyung-Soo
    Akunda, Jacqueline K.
    Langenbach, Robert
    [J]. CANCER RESEARCH, 2007, 67 (05) : 2015 - 2021
12345678910