Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

被引：35

作者：

Konger, Raymond L. ^{[1
,2
]}

Marathe, Gopal K. ^{[3
]}

Yao, Yongxue ^{[2
,4
]}

Zhang, Qiwei ^{[2
,4
]}

Travers, Jeffrey B. ^{[2
,4
,5
,6
]}

机构：

[1] Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Dept Dermatol, Indianapolis, IN 46202 USA

[3] Univ Mysore, Dept Biochem, Mysore 570006, Karnataka, India

[4] Indiana Univ, HB Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

[5] Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA

[6] Richard L Roudebush VA Med Ctr, Indianapolis, IN 46202 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2008年 / 87卷 / 1-4期

关键词：

Oxidation; Ultraviolet rays; Peroxisome proliferator-activated receptor gamma; Platelet-activating factor receptor; Glycerophosphoscholines;

D O I：

10.1016/j.prostaglandins.2008.04.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1 / 8

页数：8

共 101 条

[1] Acute keratinocyte damage stimulates platelet-activating factor production [J].

Alappatt, C ;

Johnson, CA ;

Clay, KL ;

Travers, JB .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 2000, 292 (05) :256-259

[2] Fatty acid transduction of nitric oxide signaling - Multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands [J].

Baker, PRS ;

Lin, YM ;

Schopfer, FJ ;

Woodcock, SR ;

Groeger, AL ;

Batthyany, C ;

Sweeney, S ;

Long, MH ;

Iles, KE ;

Baker, LMS ;

Branchaud, BP ;

Chen, YQE ;

Freeman, BA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (51) :42464-42475

[3] Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line [J].

Barber, LA ;

Spandau, DF ;

Rathman, SC ;

Murphy, RC ;

Johnson, CA ;

Kelley, SW ;

Hurwitz, SA ;

Travers, JB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (30) :18891-18897

[4] Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair [J].

Bartsch, Helmut ;

Nair, Jagadeesan .

LANGENBECKS ARCHIVES OF SURGERY, 2006, 391 (05) :499-510

[5]

BLACK HS, 1985, CANCER RES, V45, P6254

[6]

BLACK HS, 1987, FASEB J, V46, P1901

[7] UVB irradiation modulates systemic immune responses by affecting cytokine production of antigen-presenting cells [J].

Boonstra, A ;

van Oudenaren, A ;

Barendregt, B ;

An, LG ;

Leenen, PJM ;

Savelkoul, HFJ .

INTERNATIONAL IMMUNOLOGY, 2000, 12 (11) :1531-1538

[8] Peroxisome proliferator-activated receptor-γ-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis [J].

Bright, JJ ;

Natarajan, C ;

Muthian, G ;

Barak, Y ;

Evans, RM .

JOURNAL OF IMMUNOLOGY, 2003, 171 (11) :5743-5750

[9] n-3 and n-6 polyunsaturated fatty acids induce the expression of COX-2 via PPARγ activation in human keratinocyte HaCaT cells [J].

Chene, Gerald ;

Dubourdeau, Marc ;

Balard, Patricia ;

Escoubet-Lozach, Laure ;

Orfila, Claudine ;

Berry, Antoine ;

Bernad, Jose ;

Aries, Marie-Francoise ;

Charveron, Marie ;

Pipy, Bernard .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2007, 1771 (05) :576-589

[10] Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4 [J].

Chun, Kyung-Soo ;

Akunda, Jacqueline K. ;

Langenbach, Robert .

CANCER RESEARCH, 2007, 67 (05) :2015-2021

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