Flavanols and procyanidins of cocoa and chocolate inhibit growth and polyamine biosynthesis of human colonic cancer cells

被引：96
作者：
Carnésecchi, S
Schneider, Y
Lazarus, SA
Coehlo, D
Gossé, F
Raul, F
机构：
[1] IRCAD, Lab Nutr Chemoprevent Digest Oncol, F-67091 Strasbourg, France
[2] Mars Inc Res & Dev, Hackettstown, NJ 07840 USA
[3] IRCAD, Mol Oncol Lab, F-67091 Strasbourg, France
来源：
CANCER LETTERS | 2002年 / 175卷 / 02期
关键词：
caco-2; cell; polyphenols; cell cycle; ornithine decarboxylase; putrescine;
D O I：
10.1016/S0304-3835(01)00731-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The effects of cocoa powder and extracts with different amounts of flavanols and related procyanidin oligomers were investigated on the growth of Caco-2 cells. Treatment of the cells with 50 mug/ml of procyanidin-enriched (PE) extracts caused a 70% growth inhibition with a blockade of the cell cycle at the G2/M phase. PE extracts caused a significant decrease of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities, two key enzymes of polyamine biosynthesis. This led to a decrease in the intracellular pool of the polyamines. These observations indicate that polyamine metabolism might be an important target in the anti-proliferative effects of cocoa polyphenols. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：147 / 155
页数：9
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