Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey

被引：11
作者：
Arvas, Ahmet [1 ]
Cokugras, Haluk [1 ]
Gur, Emel [1 ]
Gonullu, Nevriye [2 ]
Taner, Zeynep [2 ]
Tokman, Hrisi Bahar [2 ]
机构：
[1] Istanbul Univ, Dept Paediat, Cerrahpasa Sch Med, Istanbul, Turkey
[2] Istanbul Univ, Dept Med Microbiol, Cerrahpasa Sch Med, Istanbul, Turkey
来源：
BALKAN MEDICAL JOURNAL | 2017年 / 34卷 / 04期
关键词：
Children; nasopharyngeal carriage; pneumococcal conjugate vaccine; Streptococcus pneumoniae; STREPTOCOCCUS-PNEUMONIAE; SEROTYPE DISTRIBUTION; DAY-CARE; IMPACT; 13-VALENT; 7-VALENT; IMMUNOGENICITY; COLONIZATION; RESISTANCE; DYNAMICS;
D O I：
10.4274/balkanmedj.2016.1256
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aims: To determine the prevalence of nasopharyngeal carriage of Streptococcus pneumoniae in healthy children aged 0-6 years who were vaccinated with pneumococcal conjugate vaccine. Methods: This cross-sectional study was conducted on 150 healthy Turkish children between 1 month and 6 years of age. Serotyping was performed and risk factors of carriage were evaluated. Results: The overall carriage rate was 14%. Vaccine type serotypes were determined in 17 (12.6%) children who received full-dose PCV13 vaccine. The highest carriage rate was observed among children younger than 24 months (76.2%). In multivariate analysis, respiratory infection in recent months, age, attendance at a day-care center and antibiotic usage were not statistically significant risk factors for carriage. Overall, S. pneumoniae strains were considered as penicillin susceptible and antimicrobial resistance was limited. Conclusion: We observed a low rate of pneumococcal carriage in children after PCV13 implementation compared with that of children receiving PCV7. Although it was reduced, vaccine serotype colonization in PCV13-vaccinated children remains persistent.
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页码：362 / 366
页数：5
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