Development of a nomogram incorporating serum C-reactive protein level to predict overall survival of patients with advanced urothelial carcinoma and its evaluation by decision curve analysis

被引：27
作者：
Ishioka, J. [1 ]
Saito, K. [1 ]
Sakura, M. [1 ]
Yokoyama, M. [1 ]
Matsuoka, Y. [1 ]
Numao, N. [1 ]
Koga, F. [1 ]
Masuda, H. [1 ]
Fujii, Y. [1 ]
Kawakami, S. [1 ]
Kihara, K. [1 ]
机构：
[1] Tokyo Med & Dent Univ, Dept Urol, Bunkyo Ku, Tokyo 1138510, Japan
来源：
BRITISH JOURNAL OF CANCER | 2012年 / 107卷 / 07期
关键词：
C-reactive protein; advanced urothelial carcinoma; biomarker; survival prediction; nomogram; decision curve analysis; TRANSITIONAL-CELL CARCINOMA; LONG-TERM-SURVIVAL; PROGNOSTIC-FACTORS; BLADDER-CANCER; MODELS; INFLAMMATION; CISPLATIN; IMPACT;
D O I：
10.1038/bjc.2012.254
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: The purpose of this study is to investigate the prognostic impact of C-reactive protein (CRP) on patients with advanced urothelial carcinoma and to develop a novel nomogram predicting survival. METHODS: A total of 223 consecutive patients were treated at Tokyo Medical and Dental Hospital. A nomogram incorporating V was developed based on the result of a Cox proportional hazards model. Its efficacy and clinical usefulness was evaluated by concordance index (c-index) and decision curve analysis. RESULTS: Of the 223 patients, 184 (83%) died of cancer. Median follow-up periods of patients who died and those who remained alive were 5 and 11 months, respectively. We developed a novel nomogram incorporating Eastern Cooperative Oncology Group Performance Status, presence of visceral metastasis, haemoglobin and age. The c-index of the nomogram predicting survival probability 6 and 12 months after diagnosis was 0.788 and 0.765, respectively. Decision curve analyses revealed that the novel nomogram incorporating CRP had a superior net benefit than that without CRP for most of the examined probabilities. CONCLUSION: We demonstrated the prognostic impact of CRP that improved the predictive accuracy of a nomogram for survival probability in patients with advanced urothelial carcinoma. British Journal of Cancer (2012) 107, 1031-1036. doi:10.1038/bjc.2012.254 www.bjcancer.com Published online 23 August 2012 (c) 2012 Cancer Research UK
引用
收藏
页码：1031 / 1036
页数：6
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