Clearance of Treatment Refractory Adenoviremia via Adenovirus-specific Donor T-Cell Transfer During Aplasia After αβTCR-CD19-Depleted Stem Cell Transplantation

被引：3
|
作者：
Goessling, Katharina L. [1 ]
Fouz, Hiba [1 ]
Kyrillopoulou, Olga [1 ]
Aubin, Matthias [1 ]
Maecker-Kolhoff, Britta [2 ]
Adams, Ortwin [3 ]
Borkhardt, Arndt [1 ]
Babor, Florian [1 ]
Schuster, Friedhelm R. [1 ]
Siepermann, Meinolf [1 ]
Schumm, Michael [4 ]
Lang, Peter [4 ]
Eiz-Vesper, Britta [5 ]
Meisel, Roland [1 ]
机构：
[1] Heinrich Heine Univ, Fac Med, Div Pediat Stem Cell Therapy, Clin Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany
[2] Hannover Med Sch, Dept Pediat Hematol & Oncol, Dusseldorf, Germany
[3] Heinrich Heine Univ, Inst Virol, Dusseldorf, Germany
[4] Univ Hosp Tubingen, Childrens Hosp, Tubingen, Germany
[5] Hannover Med Sch, Inst Transfus Med, Hannover, Germany
来源：
CLINICAL INFECTIOUS DISEASES | 2019年 / 68卷 / 08期
关键词：
adenovirus; adenoviremia; haploidentical stem cell transplantation; adoptive T-cell transfer; adenovirus-specific T cells; INFECTION; CHILDREN; HSCT;
D O I：
10.1093/cid/ciy820
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Here, we report the case of severe adenoviremia in a 7-yearold boy with highly-resistant, acute leukemia. A combined approach of alpha beta TCR-CD19-depleted stem cell transplantation, enabling immunosuppression-free post-transplant care, and early transfer of adenovirus-specific donor T cells during aplasia resulted in rapid and complete clearance of the treatment-refractory adenoviremia.
引用
收藏
页码：1406 / 1409
页数：4
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