Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2

被引：430
|
作者：
Kim, SF
Huri, DA
Snyder, SH
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
来源：
SCIENCE | 2005年 / 310卷 / 5756期
关键词：
D O I：
10.1126/science.1119407
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs.
引用
收藏
页码：1966 / 1970
页数：5
相关论文
共 50 条
  • [1] Atorvastatin activates cyclooxygenase-2 in the heart via S-nitrosylation by inducible nitric oxide synthase
    Bimbaum, Yochai
    Ye, Yumei
    Lin, Yu
    Freeberg, Sheldon
    Martinez, Juan
    Perez-Polo, Jose R.
    Uretsky, Barry F.
    CIRCULATION RESEARCH, 2006, 99 (05) : E45 - E45
  • [2] Mercury induces the expression of cyclooxygenase-2 and inducible nitric oxide synthase
    Park, Hye-Jeong
    Youn, Hyung-Sun
    TOXICOLOGY AND INDUSTRIAL HEALTH, 2013, 29 (02) : 169 - 174
  • [3] Role of cyclooxygenase-2 and inducible nitric oxide synthase in pancreatic cancer
    Kong, G
    Kim, EK
    Kim, WS
    Lee, KT
    Lee, YW
    Lee, JK
    Paik, SW
    Rhee, JC
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2002, 17 (08) : 914 - 921
  • [4] Expression and localization of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus.
    Fu, S
    Ramanujam, KS
    Meltzer, SJ
    Wilson, KT
    GASTROENTEROLOGY, 1997, 112 (04) : A565 - A565
  • [5] Role of inducible nitric oxide synthase and cyclooxygenase-2 in human pancreatic adenocarcinoma
    Franco, L.
    Doria, D.
    Benini, A.
    Bassi, C.
    Bertazzoni, E.
    ANNALS OF ONCOLOGY, 2007, 18 : VII64 - VII64
  • [6] Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic cancer
    Franco, L
    Doria, D
    Bertazzoni, E
    Benini, A
    Bassi, C
    PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2004, 73 (1-2): : 51 - 58
  • [7] Potent inhibition of the inductions of inducible nitric oxide synthase and cyclooxygenase-2 by taiwaniaflavone
    Pokharel, Yuba Raj
    Yang, Jin Won
    Kim, Ji Young
    Oh, Hyun Woo
    Jeong, Hye Gwang
    Woo, Eun-Rhan
    Kang, Keon Wook
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2006, 15 (03): : 217 - 225
  • [8] Interaction between cyclooxygenase-2 and inducible nitric oxide synthase in gastric cancer
    Son, HJ
    Kim, YH
    Park, DI
    Kim, JJ
    Rhee, PL
    Paik, SW
    Choi, KW
    Song, SY
    Rhee, JC
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 2001, 33 (05) : 383 - 388
  • [9] Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas
    Wilson, KT
    Fu, SD
    Ramanujam, KS
    Meltzer, SJ
    CANCER RESEARCH, 1998, 58 (14) : 2929 - 2934
  • [10] Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epithelial cells
    Kobayashi, O
    Miwa, H
    Watanabe, S
    Tsujii, M
    Dubois, RN
    Sato, N
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2001, 281 (03): : G688 - G696
12345