Animal models of multiple sclerosis: the good, the bad and the bottom line

被引：260

作者：

Ransohoff, Richard M. ^{[1
]}

机构：

[1] Cleveland Clin, Lerner Res Inst, Neuroinflammat Res Ctr, Cleveland, OH 44106 USA

来源：

NATURE NEUROSCIENCE | 2012年 / 15卷 / 08期

基金：

美国国家卫生研究院;

关键词：

CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ENVIRONMENTAL RISK-FACTORS; CD8(+) T-CELLS; DEMYELINATING DISEASE; AXONAL DAMAGE; MOUSE MODELS; SPINAL-CORD; REMYELINATION;

D O I：

10.1038/nn.3168

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Multiple sclerosis (MS) is a spontaneous, acquired, inflammatory demyelinating disease of the human CNS. Because it involves a complex interaction between two of the most intricate biological systems, immune system and CNS, animal modeling has been critical for addressing MS pathogenesis. MS models were originally developed serendipitously more than 75 years ago. Immune-mediated, toxic, viral and genetic models of demyelination are now used to understand the manifold aspects of MS. MS treatments evolved in part from animal model research, and further progress is envisaged in large part because these systems have been continually refined and their use focused on questions whose relevance was established by studying the human disease.

引用

页码：1074 / 1077

页数：4