Highly potent antimicrobial peptide derivatives of bovine cateslytin

被引：6
作者：
Postma, T. M. [1 ]
Liskamp, R. M. J. [1 ]
机构：
[1] Univ Glasgow, Sch Chem, Joseph Black Bldg,Univ Ave, Glasgow G12 8QQ, Lanark, Scotland
来源：
RSC ADVANCES | 2016年 / 6卷 / 97期
关键词：
CHROMOGRANIN-A; ACINETOBACTER-BAUMANNII; COLISTIN RESISTANCE; TRYPTOPHAN-RICH; BAD BUGS; ANTIBACTERIAL; MEMBRANES; HYDROPHOBICITY; MECHANISMS; CHEMISTRY;
D O I：
10.1039/c6ra17944d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Antimicrobial peptides are potentially valuable antibiotics. More research is required to turn these compounds into viable therapeutics. Herein, a novel highly potent antimicrobial peptide is presented as a tool to study antimicrobial peptides. Antibacterial activity in the low micromolar range, low haemolytic activity and excellent serum stability were observed.
引用
收藏
页码：94840 / 94844
页数：5
相关论文
共 37 条
  • [21] The cation-pi interaction
    Ma, JC
    Dougherty, DA
    [J]. CHEMICAL REVIEWS, 1997, 97 (05) : 1303 - 1324
  • [22] Natural roles of antimicrobial peptides in microbes, plants and animals
    Maroti, Gergely
    Kereszt, Attila
    Kondorosi, Eva
    Mergaert, Peter
    [J]. RESEARCH IN MICROBIOLOGY, 2011, 162 (04) : 363 - 374
  • [23] Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production
    Moffatt, Jennifer H.
    Harper, Marina
    Harrison, Paul
    Hale, John D. F.
    Vinogradov, Evgeny
    Seemann, Torsten
    Henry, Rebekah
    Crane, Bethany
    Michael, Frank St.
    Cox, Andrew D.
    Adler, Ben
    Nation, Roger L.
    Li, Jian
    Boyce, John D.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (12) : 4971 - 4977
  • [24] Peptides and Peptidomimetics for Antimicrobial Drug Design
    Mojsoska, Biljana
    Jenssen, Havard
    [J]. PHARMACEUTICALS, 2015, 8 (03) : 366 - 415
  • [25] Selective lysis of bacteria but not mammalian cells by diastereomers of melittin: Structure-function study
    Oren, Z
    Shai, Y
    [J]. BIOCHEMISTRY, 1997, 36 (07) : 1826 - 1835
  • [26] The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation
    Park, Seong-Cheol
    Park, Yoonkyung
    Hahm, Kyung-Soo
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2011, 12 (09) : 5971 - 5992
  • [27] Bad Bugs, No Drugs: No ESCAPE Revisited
    Peterson, Lance R.
    [J]. CLINICAL INFECTIOUS DISEASES, 2009, 49 (06) : 992 - 993
  • [28] INTERACTION OF ANTIMICROBIAL DERMASEPTIN AND ITS FLUORESCENTLY LABELED ANALOGS WITH PHOSPHOLIPID-MEMBRANES
    POUNY, Y
    RAPAPORT, D
    MOR, A
    NICOLAS, P
    SHAI, Y
    [J]. BIOCHEMISTRY, 1992, 31 (49) : 12416 - 12423
  • [29] Archetypal tryptophan-rich antimicrobial peptides: properties and applications
    Shagaghi, Nadin
    Palombo, Enzo A.
    Clayton, Andrew H. A.
    Bhave, Mrinal
    [J]. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2016, 32 (02) : 1 - 10
  • [30] Antimicrobial peptides: new drugs for bad bugs?
    Steckbeck, Jonathan D.
    Deslouches, Berthony
    Montelaro, Ronald C.
    [J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2014, 14 (01) : 11 - 14
1234