Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

被引：32

作者：

Contaldo, Maria ^{[1
]}

Boccellino, Mariarosaria ^{[2
]}

Zannini, Giuseppa ^{[3
]}

Romano, Antonio ^{[1
]}

Sciarra, Antonella ^{[4
]}

Sacco, Alessandra ^{[5
]}

Settembre, Giuliana ^{[2
]}

Coppola, Mario ^{[2
]}

Di Carlo, Angelina ^{[6
]}

D'Angelo, Luigi ^{[1
]}

Inchingolo, Francesco ^{[7
]}

Feola, Antonia ^{[3
]}

Di Domenico, Marina ^{[2
,8
]}

机构：

[1] Univ Campania Luigi Vanvitelli, Multidisciplinary Dept Med Surg & Dent Specialtie, Naples, NA, Italy

[2] Univ Campania Luigi Vanvitelli, Dept Precis Med, Naples, NA, Italy

[3] Univ Naples Federico II, Dept Biol, Naples, NA, Italy

[4] Univ Campania Luigi Vanvitelli, Dept Expt Med, Naples, NA, Italy

[5] Fdn G Pascale IRCCS, Cell Biol & Biotherapy Unit, Tumor Natl Ist, Naples, NA, Italy

[6] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, Rome, Italy

[7] Univ Bari Aldo Moro, Sch Med, Dept Interdisciplinary Med, Bari, Italy

[8] Temple Univ, Dept Biol, Sbarro Inst Canc Res & Mol Med, Coll Sci & Technol, Philadelphia, PA 19122 USA

来源：

JOURNAL OF ONCOLOGY | 2020年 / 2020卷

关键词：

SQUAMOUS-CELL CARCINOMA; TUMOR-NECROSIS-FACTOR; P85 REGULATORY SUBUNIT; GROWTH-FACTOR RECEPTOR; PAPILLOMA-VIRUS HPV; MEDIATES CAMP-PKA; FACTOR-KAPPA-B; LICHEN-PLANUS; BREAST-CANCER; SUBMUCOUS FIBROSIS;

D O I：

10.1155/2020/9587971

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oral cancers have been proven to arise from precursors lesions and to be related to risk behaviour such as alcohol consumption and smoke. However, the present paper focuses on the role of chronic inflammation, related to chronical oral infections and/or altered immune responses occurring during dysimmune and autoimmune diseases, in the oral cancerogenesis. Particularly, oral candidiasis and periodontal diseases introduce a vicious circle of nonhealing and perpetuation of the inflammatory processes, thus leading toward cancer occurrence via local and systemic inflammatory modulators and via genetic and epigenetic factors.

引用

页数：14

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