Our microbes not only produce antibiotics, they also overproduce amino acids

被引:58
作者
Sanchez, Sergio [1 ]
Rodriguez-Sanoja, Romina [1 ]
Ramos, Allison [2 ]
Demain, Arnold L. [2 ]
机构
[1] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City, DF, Mexico
[2] Drew Univ, Charles A Dana Res Inst Sci Emeriti RISE, Madison, NJ 07940 USA
关键词
RECOMBINANT ESCHERICHIA-COLI; GAMMA-AMINOBUTYRIC-ACID; CORYNEBACTERIUM-GLUTAMICUM; L-TRYPTOPHAN; BIOTECHNOLOGICAL PRODUCTION; METHIONINE PRODUCTION; KEY ENZYMES; L-GLUTAMATE; L-THREONINE; L-ARGININE;
D O I
10.1038/ja.2017.142
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Fermentative production of amino acids is an important goal of modern biotechnology. Through fermentation, micro-organisms growing on inexpensive carbon and nitrogen sources can produce a wide array of valuable products including amino acids. The amino acid market is $8 billion and mainly impacts the food, pharmaceutical and cosmetics industries. In terms of tons of amino acids produced per year by fermentation, L-glutamate is the most important amino acid produced (3.3 million), followed by L-lysine (2.2 million). The bacteria producing these amino acids are among the top fermentation organisms with respect to titers. Corynebacterium glutamicum is the best producer.
引用
收藏
页码:26 / 36
页数:11
相关论文
共 66 条
  • [1] Improved L-leucine production by an alpha-aminobutyric acid resistant mutant of Brevibacterium lactofermentum
    AmbeOno, Y
    Sato, K
    Totsuka, K
    Yoshihara, Y
    Nakamori, S
    [J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1996, 60 (08) : 1386 - 1387
  • [2] [Anonymous], 2016, CHEM ENG NEWS, V94, P16
  • [3] Becker J., 2017, IND BIOTECHNOLOGY MI, P183
  • [4] Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development
    Becker, Judith
    Wittmann, Christoph
    [J]. CURRENT OPINION IN BIOTECHNOLOGY, 2012, 23 (05) : 718 - 726
  • [5] From zero to hero-Design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production
    Becker, Judith
    Zelder, Oskar
    Haefner, Stefan
    Schroeder, Hartwig
    Wittmann, Christoph
    [J]. METABOLIC ENGINEERING, 2011, 13 (02) : 159 - 168
  • [6] Recombineering in Corynebacterium glutamicum combined with optical nanosensors: a general strategy for fast producer strain generation
    Binder, Stephan
    Siedler, Solvej
    Marienhagen, Jan
    Bott, Michael
    Eggeling, Lothar
    [J]. NUCLEIC ACIDS RESEARCH, 2013, 41 (12) : 6360 - 6369
  • [7] Taste receptors for umami: the case for multiple receptors
    Chaudhari, Nirupa
    Pereira, Elizabeth
    Roper, Stephen D.
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2009, 90 (03) : 738S - 742S
  • [8] Rational design and metabolic analysis of Escherichia coli for effective production of L-tryptophan at high concentration
    Chen, Lin
    Zeng, An-Ping
    [J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2017, 101 (02) : 559 - 568
  • [9] Debabov Vladimir G, 2003, Adv Biochem Eng Biotechnol, V79, P113
  • [10] Improving the Production of L-Phenylalanine by Identifying Key Enzymes Through Multi-Enzyme Reaction System in Vitro
    Ding, Dongqin
    Liu, Yongfei
    Xu, Yiran
    Zheng, Ping
    Li, Haixing
    Zhang, Dawei
    Sun, Jibin
    [J]. SCIENTIFIC REPORTS, 2016, 6