The tooth - a treasure chest of stem cells

被引:31
作者
Volponi, A. A. [1 ,2 ]
Sharpe, P. T. [1 ,2 ,3 ]
机构
[1] Guys Hosp, Kings Coll London, Inst Dent, Dept Craniofacial Dev & Stem Cell Biol, London SE1 9RT, England
[2] Guys Hosp, NIHR GSTT, KCL Comprehens Biomed Res Ctr, London SE1 9RT, England
[3] Guys Hosp, Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England
关键词
HUMAN GINGIVAL FIBROBLASTS; MUCOSAL EPITHELIAL-CELLS; DENTAL-PULP CELLS; PERIODONTAL-LIGAMENT; IMMUNOMODULATORY PROPERTIES; IN-VITRO; TISSUE; TRANSPLANTATION; REPAIR; TEETH;
D O I
10.1038/sj.bdj.2013.959
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Mesenchymal stem cells can be obtained with ease from dental/oral tissue, making them an attractive source of autologous stem cells. They offer a biological solution for restoring damaged dental tissues such as vital pulp engineering, regeneration of periodontal ligament lost in periodontal disease, and for generation of complete or partial tooth structures to form biological implants. Dental mesenchymal stem cells share properties with mesenchymal stem cells from bone marrow and there is a considerable potential for these cells to be used in different stem-cell-based therapies, such as bone and muscle regeneration. In addition, their immunosuppressive-immunomodulatory properties make these cells a suitable source for treating immunodisorders like systematic lupus erythematosus. In addition, gingival tissue might also be a very good source of epithelial cells used in the treatment of severe ocular surface disorders. Being such an accessible source for different stem cells, the tooth and the attached gingival tissue (usually discarded in the clinics) represent an ideal source of autologous or allogeneic stem cells that can be used in the treatment of many clinical conditions in dentistry and medicine.
引用
收藏
页码:353 / 358
页数:6
相关论文
共 64 条
[51]   Recruitment of dental pulp cells by dentine and pulp extracellular matrix components [J].
Smith, J. G. ;
Smith, A. J. ;
Shelton, R. M. ;
Cooper, P. R. .
EXPERIMENTAL CELL RESEARCH, 2012, 318 (18) :2397-2406
[52]   Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine [J].
Sonoyama, Wataru ;
Liu, Yi ;
Fang, Dianji ;
Yamaza, Takayoshi ;
Seo, Byoung-Moo ;
Zhang, Chunmei ;
Liu, He ;
Gronthos, Stan ;
Wang, Cun-Yu ;
Shi, Songtao ;
Wang, Songlin .
PLOS ONE, 2006, 1 (01)
[53]   Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation [J].
Spaggiari, GM ;
Capobianco, A ;
Becchetti, S ;
Mingari, MC ;
Moretta, L .
BLOOD, 2006, 107 (04) :1484-1490
[54]  
Ten Cate AR., 1998, Oral histology: development, structure, and function
[55]   Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model [J].
Tsumanuma, Yuka ;
Iwata, Takanori ;
Washio, Kaoru ;
Yoshida, Toshiyuki ;
Yamada, Azusa ;
Takagi, Ryo ;
Ohno, Takahiro ;
Lin, Konghua ;
Yamato, Masayuki ;
Ishikawa, Isao ;
Okano, Teruo ;
Izumi, Yuichi .
BIOMATERIALS, 2011, 32 (25) :5819-5825
[56]   Mesenchymal stem cells: a new strategy for immunosuppression? [J].
Uccelli, Antonio ;
Pistoia, Vito ;
Moretta, Lorenzo .
TRENDS IN IMMUNOLOGY, 2007, 28 (05) :219-226
[57]   Adult Human Gingival Epithelial Cells as a Source for Whole-tooth Bioengineering [J].
Volponi, A. Angelova ;
Kawasaki, M. ;
Sharpe, P. T. .
JOURNAL OF DENTAL RESEARCH, 2013, 92 (04) :329-334
[58]   Induced pluripotent stem cell lines derived from human gingival fibroblasts and periodontal ligament fibroblasts [J].
Wada, N. ;
Wang, B. ;
Lin, N. -H. ;
Laslett, A. L. ;
Gronthos, S. ;
Bartold, P. M. .
JOURNAL OF PERIODONTAL RESEARCH, 2011, 46 (04) :438-447
[59]   Immunomodulatory Properties of Human Periodontal Ligament Stem Cells [J].
Wada, Naohisa ;
Menicanin, Danijela ;
Shi, Songtao ;
Bartold, P. Mark ;
Gronthos, Stan .
JOURNAL OF CELLULAR PHYSIOLOGY, 2009, 219 (03) :667-676
[60]   Isolation of Distinct Progenitor Stem Cell Populations from Dental Pulp [J].
Waddington, Rachel J. ;
Youde, Sarah J. ;
Lee, Chi P. ;
Sloan, Alastair J. .
CELLS TISSUES ORGANS, 2009, 189 (1-4) :268-274