Distillative Self-Sorting of Dynamic Ester Libraries

被引：28
|
作者：
Ji, Qing [1 ]
Miljanic, Ognjen S. [1 ]
机构：
[1] Univ Houston, Dept Chem, Houston, TX 77204 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 24期
基金：
美国国家科学基金会;
关键词：
THERMODYNAMICALLY-CONTROLLED CYCLIZATION; REACTIVE DISTILLATION; ESTERIFICATION; INTERCONVERSION; CATALYSTS; ACETATES;
D O I：
10.1021/jo402305p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Metal alkoxides, such as NaOt-Bu or Ti(OBu)(4), can initiate acyl exchange within complex ester libraries. Reactive distillation of such dynamic combinatorial libraries (DCLs) isolates the most volatile ester at the expense of the less volatile library members that share a constituent with it. This process can be iteratively repeated to yield up to four industrially relevant esters as pure products from a single reaction setup. An algorithm has been developed to predict reactive distillation products in DCLs of as many as 121 members.
引用
收藏
页码：12710 / 12716
页数：7
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