Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score

被引：92

作者：

Lam, John S.

Seligson, David B.

Yu, Hong

Li, Ai

Eeva, Mervi

Pantuck, Allan J.

Zeng, Gang

Horvath, Steve

Belldegrun, Arie S.

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Urol, Los Angeles, CA USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biostat, Los Angeles, CA USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA USA

来源：

BJU INTERNATIONAL | 2006年 / 98卷 / 02期

关键词：

flap endonuclease 1; Gleason grade; prostate cancer; tissue microarray; tumour markers; EUKARYOTIC DNA-REPLICATION; CELL NUCLEAR ANTIGEN; GENE FEN1; EXPRESSION; IDENTIFICATION; OPTIMIZATION; MITOXANTRONE; EXONUCLEASE; MICROARRAYS; PREDNISONE;

D O I：

10.1111/j.1464-410X.2006.06224.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

To investigate the expression and potential clinical usefulness of structure-specific flap endonuclease 1 (FEN-1) in human primary prostate cancer using tissue microarray technology, as FEN-1 was recently identified to be overexpressed in CL1.1, the most aggressive clone generated from the hormone-refractory prostate cancer cell line CL1.

引用

页码：445 / 451

页数：7

共 47 条

[41] Double-strand DNA break formation mediated by flap endonuclease-1 [J].