Curative effect of sesame oil in a rat model of chronic kidney disease

被引：9

作者：

Liu, Chuan-Teng ^{[1
]}

Chien, Se-Ping ^{[2
]}

Hsu, Dur-Zong ^{[1
]}

Periasamy, Srinivasan ^{[1
]}

Liu, Ming-Yie ^{[1
,3
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, Tainan 70428, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Res Ctr Environm & Occupat Hlth & Prevent Med, Tainan 70428, Taiwan

[3] Tainan Univ Technol, Dept Food & Beverage Serv, Tainan, Taiwan

来源：

NEPHROLOGY | 2015年 / 20卷 / 12期

关键词：

chronic kidney disease; deoxycorticosterone acetate salt; Nrf2; osteopontin; sesame oil; STAGE RENAL-DISEASE; OXIDATIVE STRESS; HYPERTENSIVE-RATS; INJURY; OSTEOPONTIN; INFLAMMATION; ACTIVATION; APOPTOSIS; FIBROSIS; FAILURE;

D O I：

10.1111/nep.12524

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

AimChronic kidney disease causes a progressive and irreversible loss of renal function. We investigated the curative effect of sesame oil, a natural, nutrient-rich, potent antioxidant, in a rat model of chronic kidney disease. MethodsChronic kidney disease was induced by subcutaneously injecting uni-nephrectomized rats with deoxycorticosterone acetate (DOCA) and 1% NaCl [DOCA/salt] in drinking water. Four weeks later, the rats were gavaged with sesame oil (0.5 or 1mL/kg per day) for 7 days. Renal injury, histopathological changes, hydroxyl radical, peroxynitrite, lipid peroxidation, Nrf2, osteopontin expression, and collagen were assessed 24h after the last dose of sesame oil. ResultsBlood urea nitrogen, creatinine, urine volume, and albuminuria were significantly higher in the DOCA/salt treated rats than in control rats. Sesame oil significantly decreased these four tested parameters in DOCA/salt treated rats. In addition, creatinine clearance rate and nuclear Nrf2 expression were significantly decreased in the DOCA/salt treated rats compared to control rats. Sesame oil significantly decreased hydroxyl radical, peroxynitrite level, lipid peroxidation, osteopontin, and renal collagen deposition, but increased creatinine clearance rate and nuclear Nrf2 expression in DOCA/salt treated rats. ConclusionWe conclude that supplementation of sesame oil mitigates DOCA/salt induced chronic kidney disease in rats by activating Nrf2 and attenuating osteopontin expression and inhibiting renal fibrosis in rats. Summary at a Glance The authors found that supplementation of sesame oil mitigates DOCA/salt induced chronic kidney disease in rats by activating nuclear Nrf2 and attenuating osteopontin expression and inhibiting renal fibrosis in rats.

引用

页码：922 / 930

页数：9

共 30 条

[1] The Nrf2-Keapl defence pathway: Role in protection against drug-induced toxicity [J].

Copple, Ian M. ;

Goldring, Christopher E. ;

Kitteringham, Neil R. ;

Park, B. Kevin .

TOXICOLOGY, 2008, 246 (01) :24-33

[2] Prevalence of chronic kidney disease in the United States [J].

Coresh, Josef ;

Selvin, Elizabeth ;

Stevens, Lesley A. ;

Manzi, Jane ;

Kusek, John W. ;

Eggers, Paul ;

Van Lente, Frederick ;

Levey, Andrew S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (17) :2038-2047

[3] Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds [J].

Hamada, Nanako ;

Tanaka, Arisa ;

Fujita, Yasunori ;

Itoh, Tomohiro ;

Ono, Yoshiko ;

Kitagawa, Yoshinori ;

Tomimori, Namino ;

Kiso, Yoshinobu ;

Akao, Yukihiro ;

Nozawa, Yoshinori ;

Ito, Masafumi .

BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (06) :1959-1965

[4] Linking the population epidemiology of acute renal failure, chronic kidney disease and end-stage renal disease [J].

Hsu, Chi-yuan .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2007, 16 (03) :221-226

[5] The effect of sesamol on systemic oxidative stress and hepatic dysfunction in acutely iron-intoxicated mice [J].

Hsu, Dur-Zong ;

Chien, Se-Ping ;

Chen, Ke-Ting ;

Liu, Ming-Yie .

SHOCK, 2007, 28 (05) :596-601

[6] PROTECTIVE EFFECT OF DAILY SESAME OIL SUPPLEMENT ON GENTAMICIN-INDUCED RENAL INJURY IN RATS [J].

Hsu, Dur-Zong ;

Liu, Chuan-Teng ;

Li, Ya-Hui ;

Chu, Pei-Yi ;

Liu, Ming-Yie .

SHOCK, 2010, 33 (01) :88-92

[7] Sesame oil attenuates multiple organ failure and increases survival rate during endotoxemia in rats [J].

Hsu, DZ ;

Liu, MY .

CRITICAL CARE MEDICINE, 2002, 30 (08) :1859-1862

[8]

Hsu DZ, 2013, BIOMED RES INT, V2013

[9] Osteopontin deficiency protects against aldosterone-induced inflammation, oxidative stress, and interstitial fibrosis in the kidney [J].

Irita, Jun ;

Okura, Takafumi ;

Jotoku, Masanori ;

Nagao, Tomoaki ;

Enomoto, Daijiro ;

Kurata, Mie ;

Desilva, Veena Rasika ;

Miyoshi, Ken-ichi ;

Matsui, Yutaka ;

Uede, Toshimitsu ;

Denhardt, David T. ;

Rittiling, Susan R. ;

Higaki, Jitsuo .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2011, 301 (04) :F833-F844

[10] Matrix metalloproteinase 2 induces epithelial-mesenchymal transition in proximal tubules from the luminal side and progresses fibrosis in mineralocorticoid/salt-induced hypertensive rats [J].

Iwazu, Yoshitaka ;

Muto, Shigeaki ;

Hirahara, Ichiro ;

Fujisawa, Genro ;

Takeda, Shin-ichi ;

Kusano, Eiji .

JOURNAL OF HYPERTENSION, 2011, 29 (12) :2440-2453

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