BRAIN IL-6 AND AUTISM

被引：112

作者：

Wei, H. ^{[1
]}

Alberts, I. ^{[2
]}

Li, X. ^{[3
]}

机构：

[1] Shanxi Med Univ, Cent Lab, Shanxi Prov Peoples Hosp, Taiyuan 030012, Peoples R China

[2] CUNY, Dept Nat Sci, LaGuardia CC, New York, NY 11101 USA

[3] New York State Inst Basic Res Dev Disabil, Dept Neurochem, Staten Isl, NY 10314 USA

来源：

NEUROSCIENCE | 2013年 / 252卷

基金：

中国国家自然科学基金;

关键词：

autism; brain; Interleukin-6; neuroimmune response; behavior; CEREBELLAR GRANULE NEURONS; DENDRITIC SPINE DENSITY; INTERLEUKIN-6; IL-6; IMMUNE ACTIVATION; GENE-EXPRESSION; CHILDREN; DIFFERENTIATION; INFECTION; ELEVATION; ALTERS;

D O I：

10.1016/j.neuroscience.2013.08.025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autism is a severe neurodevelopmental disorder characterized by impairments in social interaction, deficits in verbal and non-verbal communication, and repetitive behavior and restricted interests. Emerging evidence suggests that aberrant neuroimmune responses may contribute to phenotypic deficits and could be appropriate targets for pharmacologic intervention. Interleukin (IL)-6, one of the most important neuroimmune factors, has been shown to be involved in physiological brain development and in several neurological disorders. For instance, findings from postmortem and animal studies suggest that brain IL-6 is an important mediator of autism-like behaviors. In this review, a possible pathological mechanism behind autism is proposed, which suggests that IL-6 elevation in the brain, caused by the activated glia and/or maternal immune activation, could be an important inflammatory cytokine response involved in the mediation of autism-like behaviors through impairments of neuroanatomical structures and neuronal plasticity. Further studies to investigate whether IL-6 could be used for therapeutic interventions in autism would be of great significance. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：320 / 325

页数：6

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