Peptidoglycan recognition proteins in Drosophila immunity

被引：195

作者：

Kurata, Shoichiro ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi 9808578, Japan

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2014年 / 42卷 / 01期

基金：

日本科学技术振兴机构; 日本学术振兴会; 美国国家卫生研究院;

关键词：

Pattern recognition receptor; Peptidoglycan recognition protein; Antimicrobial defense; Prophenoloxidase cascade; Innate immunity; Drosophila; GRAM-POSITIVE BACTERIA; PGRP-LC; NEGATIVE BACTERIA; INNATE IMMUNITY; HOST-DEFENSE; TOLL; ACTIVATION; RECEPTOR; INFECTION; LB;

D O I：

10.1016/j.dci.2013.06.006

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Innate immunity is the front line of self-defense against infectious non-self in vertebrates and invertebrates. The innate immune system is mediated by germ-line encoding pattern recognition molecules (pathogen sensors) that recognize conserved molecular patterns present in the pathogens but absent in the host. Peptidoglycans (PGN) are essential cell wall components of almost all bacteria, except mycoplasma lacking a cell wall, which provides the host immune system an advantage for detecting invading bacteria. Several families of pattern recognition molecules that detect PGN and PGN-derived compounds have been indentified, and the role of PGRP family members in host defense is relatively well-characterized in Drosophila. This review focuses on the role of PGRP family members in the recognition of invading bacteria and the activation and modulation of immune responses in Drosophila. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：36 / 41

页数：6

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