Evaluation of Anti-Mycobacterial Compounds in a Silkworm Infection Model with Mycobacteroides abscessus

被引：18
|
作者：
Hosoda, Kanji [1 ,2 ]
Koyama, Nobuhiro [1 ,2 ]
Hamamoto, Hiroshi [3 ]
Yagi, Akiho [4 ]
Uchida, Ryuji [4 ]
Kanamoto, Akihiko [5 ]
Tomoda, Hiroshi [1 ,2 ]
机构：
[1] Kitasato Univ, Grad Sch Pharmaceut Sci, Dept Microbial Chem, Tokyo 1088641, Japan
[2] Kitasato Univ, Sch Pharm, Med Res Labs, Tokyo 1088641, Japan
[3] Teikyo Univ, Inst Med Mycol, Tokyo 1920395, Japan
[4] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Sendai, Miyagi 9818558, Japan
[5] OP Bio Factory Co Ltd, Uruma, Okinawa 9042234, Japan
来源：
MOLECULES | 2020年 / 25卷 / 21期
关键词：
silkworm; mycobacteria; nontuberculous mycobacteria; Mycobacterium avium complex; Mycobacteroides abscessus; antimycobacterial activity; microbial product; lariatin; nosiheptide; ohmyungsamycin; steffimycin; quinomycin; QUANTITATIVE-EVALUATION; ANTIBIOTICS; PEPTIDES; DISEASE; NOSOKOMYCINS; QUINOMYCINS;
D O I：
10.3390/molecules25214971
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Among four mycobacteria, Mycobacterium avium, M. intracellulare, M. bovis BCG and Mycobacteroides (My.) abscessus, we established a silkworm infection assay with My. abscessus. When silkworms (fifth-instar larvae, n = 5) were infected through the hemolymph with My. abscessus (7.5 x 10(7) CFU/larva) and bred at 37 degrees C, they all died around 40 h after injection. Under the conditions, clarithromycin and amikacin, clinically used antimicrobial agents, exhibited therapeutic effects in a dose-dependent manner. Furthermore, five kinds of microbial compounds, lariatin A, nosiheptide, ohmyungsamycins A and B, quinomycin and steffimycin, screened in an in vitro assay to observe anti-My. abscessus activity from 400 microbial products were evaluated in this silkworm infection assay. Lariatin A and nosiheptide exhibited therapeutic efficacy. The silkworm infection model with My. abscessus is useful to screen for therapeutically effective anti-My. abscessus antibiotics.
引用
收藏
页数：11
相关论文
共 31 条
  • [21] Evaluation of pathogenicity and therapeutic effectiveness of antibiotics using silkworm Nocardia infection model
    Mikami, Kazuhiro
    Sonobe, Kazunari
    Ishino, Keiko
    Noda, Takumi
    Kato, Mami
    Hanao, Mami
    Hamamoto, Hiroshi
    Sekimizu, Kazuhisa
    Okazaki, Mitsuhiro
    DRUG DISCOVERIES AND THERAPEUTICS, 2021, 15 (02) : 73 - 77
  • [22] Accuracy of anti-mycobacterial protein 51 antibodies as a biomarker for latent TB infection in asymptomatic HIV positive individuals: a cross-sectional diagnostic study
    Namugga, Josephine Victo
    Musubika, Carol
    Niwagaba, Stuart
    Mayito, Jonathan
    Sande, Obondo James
    BMC RESEARCH NOTES, 2025, 18 (01)
  • [23] New liposidomycin congeners produced by Streptomyces sp. TMPU-20A065, anti-Mycobacterium avium complex agents with therapeutic efficacy in a silkworm infection model
    Yagi, Akiho
    Fujiwara, Mayu
    Sato, Mayu
    Abe, Yuzu
    Uchida, Ryuji
    JOURNAL OF ANTIBIOTICS, 2024, 77 (07) : 412 - 421
  • [24] Anti-Mycobacterial Evaluation of 7-Chloro-4-Aminoquinolines and Hologram Quantitative Structure-Activity Relationship (HQSAR) Modeling of Amino-Imino Tautomers
    Bispo, Marcelle L. F.
    Lima, Camilo H. S.
    Cardoso, Laura N. F.
    Candea, Andre L. P.
    Bezerra, Flavio A. F. M.
    Lourenco, Maria C. S.
    Henriques, Maria G. M. O.
    Alencastro, Ricardo B.
    Kaiser, Carlos R.
    Souza, Marcus V. N.
    Albuquerque, Andmagaly G.
    PHARMACEUTICALS, 2017, 10 (02)
  • [25] Quantitative evaluation of cryptococcal pathogenesis and antifungal drugs using a silkworm infection model with Cryptococcus neoformans
    Matsumoto, Y.
    Miyazaki, S.
    Fukunaga, D. H.
    Shimizu, K.
    Kawamoto, S.
    Sekimizu, K.
    JOURNAL OF APPLIED MICROBIOLOGY, 2012, 112 (01) : 138 - 146
  • [26] Evaluation of therapeutic effects and pharmacokinetics of antibacterial chromogenic agents in a silkworm model of Staphylococcus aureus infection
    Fujiyuki, Tomoko
    Imamura, Katsutoshi
    Hamamoto, Hiroshi
    Sekimizu, Kazuhisa
    DRUG DISCOVERIES AND THERAPEUTICS, 2010, 4 (05) : 349 - 354
  • [27] Synthesis and in vitro evaluation of novel substituted isatin-propylene-1H-1,2,3-triazole-4-methylene-moxifloxacin hybrids for their anti-mycobacterial activities
    Yan, Xinjia
    Lv, Zaosheng
    Wen, Jing
    Zhao, Shijia
    Xu, Zhi
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 143 : 899 - 904
  • [28] Azide-alkyne cycloaddition towards 1H-1,2,3-triazole-tethered gatifloxacin and isatin conjugates: Design, synthesis and in vitro anti-mycobacterial evaluation
    Xu, Zhi
    Song, Xu-Feng
    Hu, Yuan-Qiang
    Qiang, Min
    Lv, Zao-Sheng
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 138 : 66 - 71
  • [29] Benzo[d]thiazol-2-yl(piperazin-1-yl)methanones as new anti-mycobacterial chemotypes: Design, synthesis, biological evaluation and 3D-QSAR studies
    Pancholia, Sahaj
    Dhameliya, Tejas M.
    Shah, Parth
    Jadhavar, Pradeep S.
    Sridevi, Jonnalagadda Padma
    Yogeshwari, Perumal
    Sriram, Dharmarajan
    Chakraborti, Asit K.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 116 : 187 - 199
  • [30] Environmentally benign synthesis and anti-mycobacterial evaluation of 9,10-dihydro-4-methyl-chromeno[8,7-e][1,3]oxazin-2(8H)-one derivatives
    Mathew, Bijoy P.
    Tandon, Rashmi
    Batra, Neha
    Agarwal, Drishti
    Bose, Mridula
    Gupta, Rinkoo D.
    Nath, Mahendra
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2017, 56 (12): : 1237 - 1242
1234