The Effect of Curcumin on Breast Cancer Cells

被引：128
作者：
Liu, Dongwu
Chen, Zhiwei [1 ]
机构：
[1] Shandong Univ Technol, Anal & Testing Ctr, Zibo 255049, Peoples R China
来源：
JOURNAL OF BREAST CANCER | 2013年 / 16卷 / 02期
关键词：
Breast neoplasms; Curcumin; Mitomycin C; Molecular mechanisms of pharmacological action; ANTICANCER ACTIVITY; INHIBITS PROLIFERATION; DOWN-REGULATION; IN-VITRO; SUPPRESSES; EXPRESSION; INVASION; ANGIOGENESIS; CHEMOTHERAPY; COMBINATION;
D O I：
10.4048/jbc.2013.16.2.133
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Curcumin, which is extracted from the plant Curcuma longa, has been used in the therapeutic arsenal for clinical oncology. Curcumin has chemopreventive and antitumoral activities against some aggressive and recurrent cancers. The expressions and activities of various proteins, such as inflammatory cytokines and enzymes, transcription factors, and gene-products linked with cell survivals and proliferation, can be modified by curcumin. Moreover, curcumin decreases the toxic effect of mitomycin C. Though curcumin has shown highly cytotoxic to some cancer cell lines, curcumin is insoluble and instable in water. The solubilty of curcumin could be enhanced by utilizing the solubilizing properties of rubusoside. In addition, the selective delivery of synthetic analogs or nanotechnology-based formulations of curcumin to tumors may improve the chemopreventive and chemotherapeutic effects. The focus of this short review is to describe how curcumin participates in antitumor processes in breast cancer cells.
引用
收藏
页码：133 / 137
页数：5
相关论文
共 32 条
[1]   Curcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF-7 cells [J].
Banerjee, Mithu ;
Singh, Parminder ;
Panda, Dulal .
FEBS JOURNAL, 2010, 277 (16) :3437-3448
[2]   Effect of curcumin on irradiated and estrogen-transformed human breast cell lines [J].
Calaf, Gloria M. ;
Echiburu-Chau, Carlos ;
Wen, Gengyun ;
Balajee, Adayabalam S. ;
Roy, Debasish .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2012, 40 (02) :436-442
[3]   Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cells [J].
Carroll, Candace E. ;
Ellersieck, Mark R. ;
Hyder, Salman M. .
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2008, 15 (03) :570-574
[4]   Curcumin suppresses breast tumor angiogenesis by abrogating osteopontin-induced VEGF expression [J].
Chakraborty, Goutam ;
Jain, Shalini ;
Kale, Smita ;
Raja, Remya ;
Kumar, Santosh ;
Mishra, Rosalin ;
Kundu, Gopal C. .
MOLECULAR MEDICINE REPORTS, 2008, 1 (05) :641-646
[5]   Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-κBp65 expression in breast cancer MDA-MB-231 cells [J].
Chiu, Tsung-Lang ;
Su, Chin-Cheng .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2009, 23 (04) :469-475
[6]   Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells [J].
Hua, Wen-Feng ;
Fu, Yong-Shui ;
Liao, Yi-Ji ;
Xia, Wen-Jie ;
Chen, Yang-Chao ;
Zeng, Yi-Xin ;
Kung, Hsiang-Fu ;
Xie, Dan .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2010, 637 (1-3) :16-21
[7]   1,2,3,4,6-Penta-O-galloyl-β-D-glucose, Quercetin, Curcumin and Lycopene Induce Cell-Cycle Arrest in MDA-MB-231 and BT474 Cells through Downregulation of Skp2 Protein [J].
Huang, Hsiu-Chen ;
Lin, Chih-Li ;
Lin, Jen-Kun .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (12) :6765-6775
[8]  
Ibrahim A, 2010, IN VIVO, V24, P401
[9]   Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-κB in Breast Cancer Cells and Potentiates the Growth Inhibitory Effect of Paclitaxel in a Breast Cancer Nude Mice Model [J].
Kang, Hee Joon ;
Lee, Sang Hun ;
Price, Janet E. ;
Kim, Lee Su .
BREAST JOURNAL, 2009, 15 (03) :223-229
[10]   Curcumin Inhibition of Integrin (α6β4)-Dependent Breast Cancer Cell Motility and Invasion [J].
Kim, Hong Im ;
Huang, Huang ;
Cheepala, Satish ;
Huang, Shile ;
Chung, Jun .
CANCER PREVENTION RESEARCH, 2008, 1 (05) :385-391
1234