Will GnRH antagonists improve prostate cancer treatment?

被引：46

作者：

Huhtaniemi, IlPo ^{[1
]}

White, Richard ^{[2
]}

McArdle, Craig A. ^{[3
]}

Persson, Bo-Eric ^{[4
,5
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Reprod Biol, London W12 0NN, England

[2] Ferring Res Inst Inc, San Diego, CA 92121 USA

[3] Univ Bristol, Henry Wellcome Labs Integrat Neurosci & Endocrino, Bristol BS1 3NY, Avon, England

[4] Elisabethsjukhuset, S-75226 Uppsala, Sweden

[5] Ferring Int Ctr, CH-1162 St Prex, Switzerland

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2009年 / 20卷 / 01期

关键词：

GONADOTROPIN-RELEASING-HORMONE; FOLLICLE-STIMULATING-HORMONE; MESSENGER-RNA EXPRESSION; LUTEINIZING-HORMONE; OPEN-LABEL; AGONIST TREATMENT; RAPID DESENSITIZATION; LEUPROLIDE ACETATE; SERUM TESTOSTERONE; BETA-ARRESTINS;

D O I：

10.1016/j.tem.2008.09.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Androgen ablation forms a basis for treating prostate cancer and is achieved either by surgical castration, or pharmacologically using oestrogens, anti-androgens and/or gonadotropin-releasing hormone (GnRH) analogues. GnRH antagonists (or blockers) offer a new means of treatment by directly blocking GnRH receptors. Advantages of GnRH antagonists include lack of the initial stimulation of gonadotropin and testosterone production, lack of gonadotropin microsurges and sustained follicle-stimulating hormone suppression; disadvantages include increased histamine release. This review discusses advantages and disadvantages of the GnRH antagonists currently in development, in light of receptor physiology and pre-clinical and clinical data. Comparative clinical trials will ultimately establish their efficacy in comparison to other pharmacotherapies. Therefore, continuing development and refinement is needed to improve prostate cancer treatment.

引用

页码：43 / 50

页数：8

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