Clinical and research applications of a brain tumor tissue bank in the age of precision medicine

被引：6

作者：

Snyder, James ^{[1
,2
]}

Poisson, Laila M. ^{[2
]}

Noushmehr, Houtan ^{[2
]}

Castro, Ana V. ^{[2
]}

deCarvalho, Ana C. ^{[2
]}

Robin, Adam ^{[2
]}

Mukherjee, Abir ^{[3
]}

Lee, Ian ^{[2
]}

Walbert, Tobias ^{[1
,2
]}

机构：

[1] Henry Ford Hlth Syst, Dept Neurol, 2799 W Grand Blvd, Detroit, MI 48202 USA

[2] Henry Ford Hlth Syst, Dept Neurosurg, 2799 W Grand Blvd, Detroit, MI 48202 USA

[3] Henry Ford Hlth Syst, Dept Pathol, 2799 W Grand Blvd, Detroit, MI 48202 USA

来源：

PERSONALIZED MEDICINE | 2019年 / 16卷 / 02期

关键词：

GENOMIC ANALYSIS; DRUG DEVELOPMENT; XENOGRAFT MODEL; GLIOBLASTOMA; PDGFRA; TRIALS; GROWTH; GLIOMA; EGFR;

D O I：

10.2217/pme-2018-0102

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Marked progress has been made recently in the treatment of patients with central nervous system (CNS) tumors, especially gliomas. However, because of the relative rarity of these tumors compared with other malignancies, advances in the molecular/genetic analysis leading to future targeted treatments rely on systematic, organized tissue banking. Several large multi-institutional efforts have utilized major tissue banks that have yielded valuable information that may lead to a better understanding of the pathogenesis of CNS tumors. This manuscript portrays best practices for the establishment and maintenance of a well-organized CNS tumor bank. In addition, annotation for clinical and research needs is explained. The potential benefits to clinical care, as well as basic science and translational research are also described.

引用

页码：145 / 156

页数：12

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