Mitochondrial fission and fusion

被引：169

作者：

Lee, Hakjoo ^{[1
]}

Yoon, Yisang ^{[1
]}

机构：

[1] Augusta Univ, Med Coll Georgia, Dept Physiol, 1120 Fifteenth St, Augusta, GA 30912 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2016年 / 44卷

关键词：

DYNAMIN-RELATED PROTEIN-1; DOMINANT OPTIC ATROPHY; INNER-MEMBRANE-FUSION; MAMMALIAN-CELLS; ENDOPLASMIC-RETICULUM; PROTEOLYTIC CLEAVAGE; NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE-PHOSPHORYLATION; METABOLIC-REGULATION; DRP1; RECRUITMENT;

D O I：

10.1042/BST20160129

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial fission and fusion have been recognized as critical processes in the health of mitochondria and cells. Two decades of studies have generated a great deal of information about mitochondrial fission and fusion; however, still much needs to be understood for the basic molecular mechanisms of these important cellular processes. The core protein factors for mitochondrial fission and fusion are dynamin proteins that possess membrane-remodeling properties. This short review covers a recent development and understanding of the mechanisms by which these mechanochemical enzymes mediate mitochondrial fission and fusion.

引用

页码：1725 / 1735

页数：11

共 85 条

[51] Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation [J].

MacVicar, Thomas D. B. ;

Lane, Jon D. .

JOURNAL OF CELL SCIENCE, 2014, 127 (10) :2313-2325

[52] A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division [J].

Manor, Uri ;

Bartholomew, Sadie ;

Golani, Gonen ;

Christenson, Eric ;

Kozlov, Michael ;

Higgs, Henry ;

Spudich, James ;

Lippincott-Schwartz, Jennifer .

ELIFE, 2015, 4

[53] Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1 [J].

Meeusen, Shelly ;

DeVay, Rachel ;

Block, Jennifer ;

Cassidy-Stone, Ann ;

Wayson, Sarah ;

McCaffery, J. Michael ;

Nunnari, Jodi .

CELL, 2006, 127 (02) :383-395

[54] Metabolic regulation of mitochondrial dynamics [J].

Mishra, Prashant ;

Chan, David C. .

JOURNAL OF CELL BIOLOGY, 2016, 212 (04) :379-387

[55] Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation [J].

Mishra, Prashant ;

Carelli, Valerio ;

Manfredi, Giovanni ;

Chan, David C. .

CELL METABOLISM, 2014, 19 (04) :630-641

[56] OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis [J].

Olichon, A. ;

ElAchouri, G. ;

Baricault, L. ;

Delettre, C. ;

Belenguer, P. ;

Lenaers, G. .

CELL DEATH AND DIFFERENTIATION, 2007, 14 (04) :682-692

[57] Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis [J].

Olichon, A ;

Baricault, L ;

Gas, N ;

Guillou, E ;

Valette, A ;

Belenguer, P ;

Lenaers, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (10) :7743-7746

[58] The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space [J].

Olichon, A ;

Emorine, LJ ;

Descoins, E ;

Pelloquin, L ;

Brichese, L ;

Gas, N ;

Guillou, E ;

Delettre, C ;

Valette, A ;

Hamel, CP ;

Ducommun, B ;

Lenaers, G ;

Belenguer, P .

FEBS LETTERS, 2002, 523 (1-3) :171-176

[59] Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission [J].

Osellame, Laura D. ;

Singh, Abeer P. ;

Stroud, David A. ;

Palmer, Catherine S. ;

Stojanovski, Diana ;

Ramachandran, Rajesh ;

Ryan, Michael T. .

JOURNAL OF CELL SCIENCE, 2016, 129 (11) :2170-2181

[60] Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling [J].

Otera, Hidenori ;

Miyata, Non ;

Kuge, Osamu ;

Mihara, Katsuyoshi .

JOURNAL OF CELL BIOLOGY, 2016, 212 (05) :531-544

← 1 2 3 4 5 6 7 8 9 →