Mitochondrial fission and fusion

被引：169

作者：

Lee, Hakjoo ^{[1
]}

Yoon, Yisang ^{[1
]}

机构：

[1] Augusta Univ, Med Coll Georgia, Dept Physiol, 1120 Fifteenth St, Augusta, GA 30912 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2016年 / 44卷

关键词：

DYNAMIN-RELATED PROTEIN-1; DOMINANT OPTIC ATROPHY; INNER-MEMBRANE-FUSION; MAMMALIAN-CELLS; ENDOPLASMIC-RETICULUM; PROTEOLYTIC CLEAVAGE; NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE-PHOSPHORYLATION; METABOLIC-REGULATION; DRP1; RECRUITMENT;

D O I：

10.1042/BST20160129

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial fission and fusion have been recognized as critical processes in the health of mitochondria and cells. Two decades of studies have generated a great deal of information about mitochondrial fission and fusion; however, still much needs to be understood for the basic molecular mechanisms of these important cellular processes. The core protein factors for mitochondrial fission and fusion are dynamin proteins that possess membrane-remodeling properties. This short review covers a recent development and understanding of the mechanisms by which these mechanochemical enzymes mediate mitochondrial fission and fusion.

引用

页码：1725 / 1735

页数：11

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