Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide

被引：39

作者：

Alam, Shirjel R. ^{[1
,2
]}

Stirrat, Colin ^{[1
,2
]}

Richards, Jennifer ^{[1
]}

Mirsadraee, Saeed ^{[3
,4
]}

Semple, Scott I. K. ^{[3
]}

Tse, George ^{[5
]}

Henriksen, Peter ^{[1
,2
]}

Newby, David E. ^{[1
,2
]}

机构：

[1] Univ Edinburgh, Ctr Cardiovasc Sci, Edinburgh EH16 5SA, Midlothian, Scotland

[2] Royal Infirm Edinburgh NHS Trust, Dept Cardiol, Edinburgh EH16 5SA, Midlothian, Scotland

[3] Univ Edinburgh, Clin Res Imaging Ctr, Edinburgh EH16 5SA, Midlothian, Scotland

[4] Royal Infirm Edinburgh NHS Trust, Dept Radiol, Edinburgh EH16 5SA, Midlothian, Scotland

[5] Univ Edinburgh, MRC Ctr Inflammat Res, Edinburgh EH16 5SA, Midlothian, Scotland

来源：

JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE | 2015年 / 17卷

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

USPIO; Nanoparticles; CMR; Cardiovascular imaging; Inflammation; Macrophage; ENHANCED MAGNETIC-RESONANCE; ASYMPTOMATIC CAROTID ATHEROMA; CEREBRAL-ARTERY OCCLUSION; MR SIGNAL CHARACTERISTICS; IN-VIVO MRI; ATHEROSCLEROTIC PLAQUES; CONTRAST AGENT; MYOCARDIAL-INFARCTION; HYPERLIPIDEMIC RABBITS; INFLAMMATORY BURDEN;

D O I：

10.1186/s12968-015-0183-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular Magnetic Resonance (CMR) has become a primary tool for non-invasive assessment of cardiovascular anatomy, pathology and function. Existing contrast agents have been utilised for the identification of infarction, fibrosis, perfusion deficits and for angiography. Novel ultrasmall superparamagnetic particles of iron oxide (USPIO) contrast agents that are taken up by inflammatory cells can detect cellular inflammation non-invasively using CMR, potentially aiding the diagnosis of inflammatory medical conditions, guiding their treatment and giving insight into their pathophysiology. In this review we describe the utilization of USPIO as a novel contrast agent in vascular disease.

引用

页数：9

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