Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies

被引：69

作者：

Oliveira, AMAG

Raposo, MMM

Oliveira-Campos, AMF

Machado, AEH

Puapairoj, P

Pedro, M

Nascimento, MSJ

Portela, C

Afonso, C

Pinto, M

机构：

[1] Univ Porto, Fac Farm, Ctr Estudos Quim Organ Fitoquim & Farmacol, P-4050047 Oporto, Portugal

[2] Univ Minho, Ctr Quim, P-4710 Braga, Portugal

[3] Univ Fed Uberlandia, Inst Quim, Lab Fotoquim, GFQM, BR-38408100 Uberlandia, MG, Brazil

[4] Khon Kaen Univ, Dept Pharmacol, Fac Med, Kohnkhaen, Thailand

[5] Univ Porto, Fac Farm, Microbiol Lab, P-4050047 Oporto, Portugal

[6] Univ Porto, Fac Farm, Lab Quim Organ, P-4050047 Oporto, Portugal

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 03期

关键词：

furocoumarins; benzopsoralens; antitumor; computational studies;

D O I：

10.1016/j.ejmech.2005.10.016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight psoralens have been evaluated for their ability to inhibit the in vitro growth of three human turner cell lines representing different tumor types, MCF-7 (breast cancer), NCI-14460 (non-small cell lung cancer) and SF-268 (CNS cancer). The synthesis of four new psoralens (benzofur-ocournarins) is presented as well as the results of the ab initio calculations to find the parameters that relate the structure with the antitumor activity. This work provides supplementary information that could allow the development of new psoralen analogues with this type of biological activity. (c) 2006 Elsevier SAS. All rights reserved.

引用

页码：367 / 372

页数：6

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