Catalyst-free one-pot synthesis and antioxidant evaluation of highly functionalized novel 1,4-dihydropyridine derivatives

被引：16

作者：

Ramesh, Rathinam ^{[1
]}

Maheswari, Subramani ^{[1
]}

Murugesan, Senniappan ^{[1
]}

Sandhiya, Raman ^{[1
]}

Lalitha, Appaswami ^{[1
]}

机构：

[1] Periyar Univ, Dept Chem, Salem 636011, Tamil Nadu, India

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2015年 / 41卷 / 11期

关键词：

1,4-Dihyropyridine; n-Propylamine; Cyclohexylamine; DPPH radical scavenging; Antioxidant activity; 3-COMPONENT SYNTHESIS; 2-AMINO-4H-PYRANS; 2-AMINO-5-OXO-5,6,7,8-TETRAHYDRO-4H-CHROMENES; INHIBITORS; DISCOVERY; ACID;

D O I：

10.1007/s11164-014-1887-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalyst-free greener protocol for the most effective one-pot synthesis of 2,6-diamino-4-aryl-1-propyl/cyclohexyl-1,4-dihydropyridine-3,5-dicarbonitrile derivatives has been developed using a simple three-component reaction of structurally diverse aldehydes, malononitrile and n-propylamine/cyclohexylamine at an ambient temperature. The formation of 1,4-dihydropyridines could be achieved in aqueous methanol in a single synthetic process involving no chromatography. The newly synthesized highly functionalized 1,4-DHPs have been screened for their in vitro antioxidant activity using the DPPH radical scavenging technique and the results were good in comparison with a standard drug.

引用

页码：8233 / 8243

页数：11

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