Global approach to multichannel electroencephalogram analysis for diagnosis and clinical evaluation in mild Alzheimer's disease

被引：22

作者：

Yoshimura, M ^{[1
]}

Isotani, T ^{[1
]}

Yagyu, T ^{[1
]}

Irisawa, S ^{[1
]}

Yoshida, T ^{[1
]}

Sugiyama, M ^{[1
]}

Minami, T ^{[1
]}

Sugimoto, T ^{[1
]}

Nobuhara, K ^{[1
]}

Okugawa, G ^{[1
]}

Kinoshita, T ^{[1
]}

机构：

[1] Kansai Med Univ, Dept Neuropsychiat, Osaka 5708506, Japan

来源：

NEUROPSYCHOBIOLOGY | 2004年 / 49卷 / 03期

关键词：

Alzheimer's disease; electroencephalogram; global approach; generalized frequency; cognitive function;

D O I：

10.1159/000076724

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To establish an early diagnosis of Alzheimer's disease (AD), we evaluated brain spatial dynamics and cognitive function in mild AD. Seventeen patients with the diagnosis of mild AD and 17 age-matched controls were examined for Omega (global complexity), Sigma (total power) and Phi (generalized frequency) by 19-channel electroencephalography ( EEG). As a result, the mild AD group showed significantly higher Omega values than the control group. The. values were highly correlated with the Mini-Mental State Examination scores and the full IQ and performance IQ scores of the Japanese Wechsler Adult Intelligence Scale Revised. These results indicate an increase in spatial complexity of the brain electric field in mild AD, as well as a close relationship between slowing of the global frequency of field changes and the cognitive decline in mild AD. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：163 / 166

页数：4

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