Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights

被引：347
|
作者：
Vallet-Regi, Maria [1 ,2 ]
Colilla, Montserrat [1 ,2 ]
Izquierdo-Barba, Isabel [1 ,2 ]
Manzano, Miguel [1 ,2 ]
机构：
[1] Univ Complutense Madrid, Dept Quim Inorgan & Bioinorgan, Fac Farm, Inst Invest Sanitaria,Hosp 12 Octubre i12, Plaza Ramon & Cajal S-N, E-28040 Madrid, Spain
[2] Ctr Invest Biomed Red Bioingn Biomat & Nanomed CI, Madrid 28040, Spain
来源：
MOLECULES | 2018年 / 23卷 / 01期
基金：
欧洲研究理事会;
关键词：
mesoporous silica nanoparticles; multifunctional nanosystem; selective targeting; stimuli-responsive drug delivery; in vitro degradation; benefits and downsides; clinical translation; biosafety; RESPONSIVE CONTROLLED-RELEASE; DUAL-TARGETED NANOCARRIER; MESENCHYMAL STEM-CELLS; IN-VITRO; DEGRADATION BEHAVIOR; ACID; MECHANISMS; THERAPY; BIOCOMPATIBILITY; NANOSPHERES;
D O I：
10.3390/molecules23010047
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to target the diseased tissue and release the cargo on demand upon exposition to internal or external stimuli. The degradation rate of these nanocarriers in diverse physiological fluids is overviewed obeying their significance for their potential translation towards clinical applications. To conclude, the balance between the benefits and downsides of this revolutionary nanotechnological tool is also discussed.
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页数：19
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