Chemically Induced Intestinal Damage Models in Zebrafish Larvae

被引：77

作者：

Oehlers, Stefan H. ^{[1
]}

Flores, Maria Vega ^{[1
]}

Hall, Christopher J. ^{[1
]}

Okuda, Kazuhide S. ^{[1
]}

Sison, John Oliver ^{[1
]}

Crosier, Kathryn E. ^{[1
]}

Crosier, Philip S. ^{[1
]}

机构：

[1] Univ Auckland, Sch Med Sci, Dept Mol Med & Pathol, Auckland 11421, New Zealand

来源：

ZEBRAFISH | 2013年 / 10卷 / 02期

关键词：

INFLAMMATORY-BOWEL-DISEASE; GENOME-WIDE ASSOCIATION; GUT MICROBIOTA; ASIA-PACIFIC; SUSCEPTIBILITY; MICE; NOD2; DIFFERENTIATION; INVOLVEMENT; EXPRESSION;

D O I：

10.1089/zeb.2012.0824

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several intestinal damage models have been developed using zebrafish, with the aim of recapitulating aspects of human inflammatory bowel disease (IBD). These experimentally induced inflammation models have utilized immersion exposure to an array of colitogenic agents (including live bacteria, bacterial products, and chemicals) to induce varying severity of inflammation. This technical report describes methods used to generate two chemically induced intestinal damage models using either dextran sodium sulfate (DSS) or trinitrobenzene sulfonic acid (TNBS). Methods to monitor intestinal damage and inflammatory processes, and chemical-genetic methods to manipulate the host response to injury are also described.

引用

页码：184 / 193

页数：10

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